188633-71-8

Basic information

• Product Name: (S_S)-N-(N-tert-Butyloxycarbonyl-L-leucinyl)-S-methyl S-phenyl sulfoximine
• Synonyms: (S_S)-N-(N-tert-Butyloxycarbonyl-L-leucinyl)-S-methyl S-phenyl sulfoximine
• CAS NO: 188633-71-8
• Molecular Weight: 368.497
• Mol File: 188633-71-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S_S)-N-(N-tert-Butyloxycarbonyl-L-leucinyl)-S-methyl S-phenyl sulfoximine(CAS DataBase Reference)
• NIST Chemistry Reference: (S_S)-N-(N-tert-Butyloxycarbonyl-L-leucinyl)-S-methyl S-phenyl sulfoximine(188633-71-8)
• EPA Substance Registry System: (S_S)-N-(N-tert-Butyloxycarbonyl-L-leucinyl)-S-methyl S-phenyl sulfoximine(188633-71-8)

Safety Data

• Hazardous Substances Data: 188633-71-8(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 4381-25-3 (S)-S-methyl-S-phenylsulfoximine 

Downstream Products

• 188633-85-4 (S_S)-N-(N-tert-butyloxycarbonyl-L-leucinyl S-phenyl sulfonimidoyl methyl)-N-(O-allyl-L-leucinyl)carboxyamide 

Relevant articles and documents

A mild synthetic procedure for the preparation of N-alkylated sulfoximines

N-Alkylated sulfoximines have been synthesized in good yields by acylation of NH-sulfoximines followed by carbonyl reduction with complexed boranes. Enantiopure substrates react without racemization, and stereogenic centers originating from the acylating component are retained. If the acylation is performed by DCC coupling, this two-step procedure represents a rare example of a formal N-alkylation of sulfoximines under base-free conditions.

Sulfoximines in pseudopeptides

Syntheses of sulfoximine-containing pseudopeptides of type 2 are reported. Intramolecurar hydrogen bonds have been revealed by NMR spectroscopy.