18865-31-1Relevant academic research and scientific papers
METHOD FOR THE SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID
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Page/Page column 23, (2014/02/15)
The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P-O-P anhydride moiety comprising compound, having one P-atom at the oxidation state (+111) and the other P-atom at the oxidation state (+111) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P-O-P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.
A PRACTICAL SYNTHESIS OF α-AMINOPHOSPHONIC ACIDS
Genet, J. P.,Uziel, J.,Port, M.,Touzin, A. M.,Roland, S.,et al.
, p. 77 - 80 (2007/10/02)
The preparation of diterbutyl-N (diphenylmethylene) aminomethylphosphonate 3 in four steps (42percent overall yield) from N-hydroxymethyl phthalimide 1 is described.Various α substituted α-aminophosphonic acids 5 containing functionalized unsaturated chains have been synthesized by alkylation of 3 under phase transfer catalysis with halides, Michael acceptors and palladium promoted reactions, followed by mild hydrolysis. Key words: Schiff bases of diterbutylaminomethylphosphonate; phase transfer catalysis; palladium-catalyzed allylic substitution; Michael additions.
ORGANISCHE PHOSPHORVERBINDUNGEN. 79. HERSTELLUNG UND EIGENSCHAFTEN VON &α-AMINO-ω-CARBOXYALKYLPHOSPHON- UND PHOSPHINSAEUREN
Diel, Peter J.,Maier, Ludwig
, p. 201 - 210 (2007/10/02)
The synthesis, chemical and spectral properties of α-amino-ω-carboxyalkylphosphonic acids, (HO)2P(O)CH(NH2)(CH2)xCO2H, x=2 to 6, and α-amino-ω-carboxyalkyl-methylphosphonic acids CH3(HO)P(O)CH(NH2)(CH2)xCO2H, x=2 to 6 are described and the fungicidal acti
New Phosphonic Analogs of Aspartic and Glutamic Acid by Aminoalkylation of Trivalent Phosphorus Chlorides with Ethyl Acetyloacetate or Ethyl Levulinate and Benzyl Carbamate
Oleksyszyn, Jozef,Gruszecka, Ewa,Kafarski, Pawel,Mastalerz, Przemyslaw
, p. 59 - 72 (2007/10/02)
Preparation of the phosphonic analogs of α-methylaspartic (4 a-d), glutamic (7 a-b) and α-methylpyroglutamic (5 a-b) acids by aminoalkylation of trivalent phosphorus chlorides with ethyl esters of oxoalkyloacids and benzyl carbamate is described.The phosp
