18867-43-1

Basic information

• Product Name: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL
• Synonyms: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL;(1R)-2-amino-1-phenylethanol,hydrochloride
• CAS NO: 18867-43-1
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 0
• EINECS: 1308068-626-2
• Mol File: 18867-43-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL(18867-43-1)
• EPA Substance Registry System: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL(18867-43-1)

Safety Data

• Hazardous Substances Data: 18867-43-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is used as a chiral building block for the synthesis of pharmaceuticals, contributing to the development of enantiomerically pure drugs with improved efficacy and reduced side effects.
Used in Organic Chemistry:
(R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is used as a versatile starting material in asymmetric synthesis, enabling the preparation of various chiral compounds with specific biological activities.
Used in Asymmetric Catalysis:
(R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is used as a chiral ligand in asymmetric catalysis, enhancing the selectivity and efficiency of chemical reactions to produce enantiomerically pure products.
Used in Racemic Mixture Resolution:
(R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is used as a resolving agent for racemic mixtures, facilitating the separation of enantiomers and contributing to the production of pure enantiomers for various applications.
Used in Drug Discovery and Development:
(R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is used in the investigation of its potential pharmacological and therapeutic properties, with implications in the treatment of various medical conditions and the advancement of novel therapeutic agents.

InChI:InChI=1/C8H11NO.ClH/c9-6-8(10)7-4-2-1-3-5-7;/h1-5,8,10H,6,9H2;1H/t8-;/m0./s1

Upstream product

• 4561-43-7 2-amino-1-phenylethanol hydrochloride 
• 141377-54-0 2-nitro-1-phenylethan-1-ol 
• 10020-96-9 (R)-Mandelonitrile 
• 5468-37-1 2-aminoacetophenone hydrochloride 

Downstream Products

• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 391901-45-4 YM-208876 

Relevant articles and documents

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Asymmetric Hydrogenation of α, β, and γ-Aminoketones Catalyzed by Cationic Rhodium(I){AMPP} Complexes

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Efficient asymmetric hydrogenation of α-amino ketone derivatives. A highly enantioselective synthesis of phenylephrine, levamisole, carnitine and propranolol

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The Cyclic Dipeptide cyclo as a Catalyst for Asymmetric Addition of Hydrogen Cyanide to Aldehydes

cyclo (cyclo, 1) catalyzes the addition of hydrogen cyanide to benzaldehyde in toluene at -20 deg C to afford (R)-mandelonitrile with enantiomeric excess of 97 percent in high yield. cyclo gives (S)-mandelonitrile. cyclo (1) exhibits a broad substrate specificity, and a variety of aldehydes (3a-r) such as m-methoxybenzaldehyde (3c), 6-methoxy-2-naphthaldehyde (3k), and isobutyraldehyde (3o) similarly afforded the corresponding cyanohydrins with high enantiopurities (97 percent ee for 3c, 93 percent ee for 3k, 71 percent ee for 3o). (R)-Mandelonitrile thus obtained was successfully converted to various chiral synthons such as mandelic acid (7), methyl mandelate (8), and 2-amino-1-phenylethanol (9) without any racemization.