188714-75-2Relevant academic research and scientific papers
Aromatic amidine derivatives useful as selective thrombin inhibitors
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, (2008/06/13)
The present invention relates to a novel thrombin inhibitor which is effective even when orally administered. More specifically, the present invention relates to an aromatic amidine derivative represented by formula (I) and the salts thereof, which show potent selective inhibitory activity for thrombin in which (a), R, R1, R2, R3, A, W, Y and n are defined as described in the specification.
The conformation and activity relationship of benzofuran derivatives as angiotensin II receptor antagonists
Yoo, Sung-Eun,Lee, Seung-Heui,Kim, Soo-Kyung,Lee, Sung-Hou
, p. 445 - 459 (2007/10/03)
We have synthesized various benzofuran derivatives to study the relationship between the conformation and the angiotensin II type I receptor antagonistic activity.
