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188730-11-2

4-[(1E,5Z)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-2,10-dimethyl-undeca-1,5-dienyl]-2-methyl-thiazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 188730-11-2 Structure

  • Basic information

    1. Product Name: 4-[(1E,5Z)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-2,10-dimethyl-undeca-1,5-dienyl]-2-methyl-thiazole
    2. Synonyms: 4-[(1E,5Z)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-2,10-dimethyl-undeca-1,5-dienyl]-2-methyl-thiazole
    3. CAS NO:188730-11-2
    4. Molecular Formula:
    5. Molecular Weight: 537.998
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 188730-11-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[(1E,5Z)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-2,10-dimethyl-undeca-1,5-dienyl]-2-methyl-thiazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[(1E,5Z)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-2,10-dimethyl-undeca-1,5-dienyl]-2-methyl-thiazole(188730-11-2)
    11. EPA Substance Registry System: 4-[(1E,5Z)-(3S,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-2,10-dimethyl-undeca-1,5-dienyl]-2-methyl-thiazole(188730-11-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 188730-11-2(Hazardous Substances Data)

188730-11-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 188730-11-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,7,3 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 188730-11:
(8*1)+(7*8)+(6*8)+(5*7)+(4*3)+(3*0)+(2*1)+(1*1)=162
162 % 10 = 2
So 188730-11-2 is a valid CAS Registry Number.

188730-11-2Downstream Products

188730-11-2Relevant articles and documents

Total syntheses of epothilones A and B via a macrolactonization-based strategy

Nicolaou,Ninkovic,Sarabia,Vourloumis,He,Vallberg,Finlay,Yang

, p. 7974 - 7991 (2007/10/03)

The total syntheses of epothilones A (1) and B (2) and several analogues thereof are described. The reported strategy relies on a macrolactonization approach and features selective epoxidation of the macrocycle double bond in precursors 3 and 4 (Scheme 1), respectively, as well as high convergency and flexibility. Building blocks 9-12 and 15 were constructed by asymmetric processes and coupled via Wittig, aldol, and macrolactonization reactions to afford the basic skeleton of epothilones and that of several of their analogues by a relatively short route. The utilization ofintermediate 14, obtained via a stereoselective Wittig reaction and its Enders coupling to SAMP hydrazone 13 (Scheme 8), in combination with a stereoselective aldol reaction with the modified substrate 69 (Scheme 10) improved the stereoselectivity and efficiency of the total synthesis of these new and highly potent microtubule binding antitumor agents.

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