18874-85-6Relevant academic research and scientific papers
Design and novel synthesis of aryl-heteroaryl-imidazole MAP kinase inhibitors
Dobler, Markus R.
, p. 7115 - 7117 (2003)
Inhibitors of the MAP kinase p38, potentially useful for the treatment of rheumatoid arthritis and inflammatory diseases, were found to exhibit antifungal activity. We have developed a new diversity-oriented strategy leading to concise and efficient syntheses of known and new members of this compound class. The strategy is based on carbon-carbon cross-coupling reactions using N-protected 4,5-diiodo-imidazoles as the starting templates.
