188747-39-9Relevant academic research and scientific papers
Diphosphine bifunctional chelators for low-valent metal ions. Crystal structures of the copper(I) complexes [CuClL12] and [CuL12][PF6] [L1 = 2,3-bis(diphenylphosphino)maleic anhydride]
Lewis, Jason S.,Heath, Sarah L.,Powell, Annie K.,Zweit, Jamal,Blower, Philip J.
, p. 855 - 861 (2007/10/03)
The chelating diphosphine 2,3-bis(diphenylphosphino)maleic anhydride (L1) reacted with CuCl to give [CuClL12] 1a in which the copper is bound to three phosphorus atoms and one chlorine in a pseudo-tetrahedral structure, as demonstrated by X-ray crystallography. Compound L1 reacted with [Cu(MeCN)4][PF6] to give the red salt [CuL12][PF6] 1b in which the copper is bound by four phosphorus atoms of two chelating bidentate ligands, as demonstrated by X-ray crystallography. Addition of chloride ions to 1b quantitatively affords 1a. Complex 1a can be converted quantitatively into [CuL12][NO3] 1c by treatment with AgNO3. These complexes reacted quantitatively with water, benzylamine and methanol to give the corresponding [CuL22]+ 2, [CuL32]+ 3 and [CuL42]+ 4 where L2 = 2,3-bis(diphenylphosphino)maleic acid and L3 and L4 are the monobenzylamide and monomethyl ester derivatives, respectively, of L2. Uncomplexed L1 can also be hydrolysed to L2 or derivatised with benzylamine or methanol to give L3 and L4 respectively. Compounds L2, L3 and L4 reacted with copper-(I) or -(II) salts to yield salts of 2, 3 and 4. This chemistry provides versatile routes to the synthesis of stable bioconjugates containing copper or radiocopper and of derivatised solids containing pendant diphosphine ligands.
