188771-20-2Relevant academic research and scientific papers
Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization
Whiting, Matthew,Tripp, Jonathan C.,Lin, Ying-Chuan,Lindstrom, William,Olson, Arthur J.,Elder, John H.,Sharpless, K. Barry,Fokin, Valery V.
, p. 7697 - 7710 (2007/10/03)
Building from the results of a computational screen of a range of triazole-containing compounds for binding efficiency to human immunodeficiency virus type 1 protease (HIV-1-Pr), a novel series of potent inhibitors has been developed. The copper(I)-cataly
