188777-54-0

Basic information

• Product Name: (R)-(+)-N-ALPHA-BENZYL-N-BETA-BOC-N-EPSILON-Z-L-HYDRAZINOMETHIONINE, RS-S-OXYDE
• Synonyms: (R)-(+)-N-ALPHA-BENZYL-N-BETA-BOC-N-EPSILON-Z-L-HYDRAZINOMETHIONINE, RS-S-OXYDE
• CAS NO: 188777-54-0
• Molecular Formula: C25H33N3O7S
• Molecular Weight: 519.61
• Mol File: 188777-54-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: 0-6°C
• CAS DataBase Reference: (R)-(+)-N-ALPHA-BENZYL-N-BETA-BOC-N-EPSILON-Z-L-HYDRAZINOMETHIONINE, RS-S-OXYDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-ALPHA-BENZYL-N-BETA-BOC-N-EPSILON-Z-L-HYDRAZINOMETHIONINE, RS-S-OXYDE(188777-54-0)
• EPA Substance Registry System: (R)-(+)-N-ALPHA-BENZYL-N-BETA-BOC-N-EPSILON-Z-L-HYDRAZINOMETHIONINE, RS-S-OXYDE(188777-54-0)

Safety Data

• Hazardous Substances Data: 188777-54-0(Hazardous Substances Data)

Usage

Chemical Properties

light beige crystalline powder

InChI:InChI=1/C17H26N2O5S/c1-17(2,3)24-16(22)18-19(12-13-8-6-5-7-9-13)14(15(20)21)10-11-25(4)23/h5-9,14H,10-12H2,1-4H3,(H,18,22)(H,20,21)/p-1/t14-,25+/m0/s1

Upstream product

• 219547-77-0 t-butyl 3-(trichloromethyl)-1,2-oxaziridine-2-carboxylate 

Relevant articles and documents

Electrophilic Amination of Amino Acids with N-Boc-oxaziridines: Efficient Preparation of N-Orthogonally Diprotected Hydrazino Acids and Piperazic Acid Derivatives

A general two-step preparation of enantiopure Nα,N β-orthogonally diprotected α-hydrazino acids 1 is developed on a multigram scale. The key reaction is the efficient electrophilic amination of N-benzyl amino acids 6 with N-Boc-oxaziridine 7 and accommodates various functional groups encountered in side chains of amino acids. The cyclic 2,3,4,5-tetrahydro-3-pyridazine carboxylic acid (piperazic acid) derivatives 2 and 3 or the cyclic 3,4-dihydro-3-pyrazolecarboxylate 4 are conveniently prepared from glutamic acid or aspartic acid via orthogonally diprotected α-hydrazino acids 1m and 1n.