188779-53-5Relevant academic research and scientific papers
Novel synthetic routes to PNA monomers and PNA-DNA linker molecules
Breipohl, Gerhard,Will, David W.,Peyman, Anusch,Uhlmann, Eugen
, p. 14671 - 14686 (2007/10/03)
Novel methods for the preparation of monomethoxytrityl (Mmt) protected aminoethylglycine building blocks and dimethoxytrityl (Dmt) protected hydroxyethylglycine derivatives useful for the synthesis of polyamide nucleic acids (PNAs) and PNA/DNA chimeras are described. The protecting group strategy employed for PNA monomer synthesis produces easily isolable intermediates, minimizes chromatographic purification, and is suitable for large-scale monomer synthesis.
