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188781-17-1

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188781-17-1 Usage

General Description

4-methyl-2-hydroxy-pyrimidine-5-carboxylic acid is a chemical compound containing a pyrimidine ring with a methyl and hydroxyl group attached at the 4 and 2 positions, respectively, and a carboxylic acid group at the 5 position. It belongs to the class of pyrimidine carboxylic acids and is a key intermediate in the synthesis of various pharmaceuticals and organic compounds. 4-methyl-2-hydroxy-pyrimidine-5-carboxylic acid has potential applications in the pharmaceutical industry as it can serve as a building block for the synthesis of antiviral and antibacterial agents. Additionally, it has been studied for its potential antioxidant and neuroprotective properties. Overall, 4-methyl-2-hydroxy-pyrimidine-5-carboxylic acid is a versatile chemical with diverse applications in medicine and industry.

Check Digit Verification of cas no

The CAS Registry Mumber 188781-17-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,7,8 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 188781-17:
(8*1)+(7*8)+(6*8)+(5*7)+(4*8)+(3*1)+(2*1)+(1*7)=191
191 % 10 = 1
So 188781-17-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H2ClF3N2O2/c7-5-11-1-2(4(13)14)3(12-5)6(8,9)10/h1H,(H,13,14)

188781-17-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names 2-chloro-4-trifluoromethylpyrimidine-5-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:188781-17-1 SDS

188781-17-1Relevant articles and documents

Metal-bearing and trifluoromethyl-substituted pyrimidines: Generation and functionalization

Schlosser, Manfred,Lefebvre, Olivier,Ondi, Levente

, p. 1593 - 1598 (2006)

5-Pyrimidyllithium species are fairly stable when the metal is flanked by two electron-withdrawing substituents such as trifluoromethyl and chlorine or bromine. Thus, the corresponding 5-carboxylic acids are produced in high yields from 4,5-dibromo-6-(trifluoromethyl)pyrimidine and 5-bromo-4-chloro-6- (trifluoromethyl)pyrimidine upon halogen/metal permutation accomplished with isopropylmagnesium chloride or butyllithium followed by carboxylation. Satisfactory or excellent yields of 5-carboxylic acids are equally obtained when 4-chloro-, 2,4-dichloro- and 2,4-dibromo-6-(trifluoromethyl)pyrimidine are deprotonated with lithium diisopropylamide before being allowed to react with dry ice. In contrast, consecutive treatment of 2-bromo-4-(trifluoromethyl) pyrimidine and 2-chloro-5-iodo-4-(trifluoromethyl)pyrimidine with butyllithium affords the expected carboxylic acids in only poor yields and not even trace amounts of acid were detected when 4-bromo-6-(trifluoromethyl)pyrimidine served as the substrate. The formation of bipyrimidines, emerging from either one of two competing mechanistic pathways, is a permanently menacing side reaction. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions

-

, (2008/06/13)

Compounds having utility as antinflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine- or pyrazine-containing compounds and, in one embodiment, are carboxyamides of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.

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