188796-24-9Relevant academic research and scientific papers
Structure-based design, synthesis, and in vitro assay of novel nucleoside analog inhibitors against HIV-1 reverse transcriptase
Liu, Xianjun,Xie, Wei,Huang, Raven H.
, p. 3775 - 3777 (2007/10/03)
Crystal structure of HIV-RT in complex with a DNA template:primer and a dTTP leads us to design and synthesize a new class of nucleoside analog inhibitors containing a branched 3′-group against HIV-RT. An in vitro primer extension assay indicates that thr
Nucleoside analog inhibitors of reverse transcriptase
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Page 8;13, (2008/06/13)
Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase: R4 is a nucleoside with Q substituting a 3′ hydroxyl group, and Q is a moiety of formulas (XXIV)-(XXXII):
