188797-80-0

Basic information

• Product Name: Ziprasidone Sulfoxide
• Synonyms: Ziprasidone Sulfoxide
• CAS NO: 188797-80-0
• Molecular Formula: C21H21ClN4O2S
• Molecular Weight: 428.93504
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 188797-80-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 145-148°C
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 13.34±0.20(Predicted)
• CAS DataBase Reference: Ziprasidone Sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: Ziprasidone Sulfoxide(188797-80-0)
• EPA Substance Registry System: Ziprasidone Sulfoxide(188797-80-0)

Safety Data

• Hazardous Substances Data: 188797-80-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale Pink Solid

Uses

Different sources of media describe the Uses of 188797-80-0 differently. You can refer to the following data:
1. A metabolite of Ziprasidone (Z485000).
2. A metabolite of Ziprasidone

Upstream product

• 122883-93-6 ziprazidone 

Relevant articles and documents

Stability-indicating spectrofluorimetric method for the assay of ziprasidone in capsules

A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of ziprasidone hydrochloride (ZPS) in capsules. The method is based on measuring the native fluorescence of ZPS in acetate buffer of pH 4.5 at 398 nm after excitation at 315 nm. The fluorescence-concentration plot was rectilinear over the range of 0.05-0.80 μg mL-1 with a lower detection limit (LOD) of 6.0 ng mL-1 and quantification limit (LOQ) of 20.0 ng mL-1. The method was fully validated and successfully applied to the determination of ZPS in its capsules with average percentage recovery of 99.7±1.4. The method was extended to stability study of ZPS. The drug was exposed to acidic, alkaline, oxidative and photolytic degradation according to ICH guidelines. Moreover, the method was utilized to investigate the kinetics of the alkaline, acidic and oxidative degradation of the drug. A proposal for the degradation pathways was postulated. Springer Science+Business Media, LLC 2009.