188813-04-9Relevant articles and documents
LIGHT INDUCED CATALYTIC C-H OXYGENATION OF ALKANES
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Paragraph 00219, (2021/04/02)
A method of oxygenating a benzylic C-H bond is provided. The method comprises light induced activation of an initiator and subsequent reaction with oxygen, resulting in the formation of free radicals. Subsequently, free radicals catalyze the reaction of the benzylic C-H bond with oxygen, thereby forming an oxygenated compound.
Visible-Spectrum Solar-Light-Mediated Benzylic C-H Oxygenation Using 9,10-Dibromoanthracene As an Initiator
Santra, Sourav K.,Szpilman, Alex M.
, p. 1164 - 1171 (2020/12/23)
We report a visible-light-mediated benzylic C-H oxygenation reaction. The reaction is initiated by solar light or the blue LED activation of 9,10-dibromoanthracene in a reaction with oxygen and takes place at ambient temperature and air pressure. Secondary benzylic positions are oxygenated to ketones, while tertiary benzylic carbons are oxygenated to give hydroperoxides. Notably, cumene hydroperoxide is produced in a higher yield and at milder conditions than the currently employed industrial conditions.
Method for synthesizing aromatic aldehyde, aromatic ketone and aromatic ester through catalytically oxidizing alkyl aromatic compound by iron
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Paragraph 0054; 0055, (2017/10/13)
The invention discloses a method for synthesizing aromatic aldehyde, aromatic ketone and aromatic ester through catalytically oxidizing an alkyl aromatic compound by iron, and belongs to the technical field of catalytic synthesis. According to the method, a low-cost and environment-friendly iron catalyst is used under a normal pressure; under the action of hydrogen and silicon reagents serving as an accelerant and an oxidant, a side chain of an aromatic hydrocarbon is oxidized into a carbonyl group for generating the corresponding aromatic aldehyde, aromatic ketone and aromatic ester. The method for preparing the aromatic aldehyde, the aromatic ketone and the aromatic ester through a catalytic oxidation reaction, which is provided by the invention, has numerous advantages that a catalyst, reaction raw materials, the oxidant and a silicon reagent are wide in sources and good in stability and is low-cost and environment-friendly; the alkyl aromatic compound is metered to participate in a reaction; the reaction condition is mild; the compatibility of functional groups is good; the scope of application is wide; the reaction selectivity is good; in an optimized reaction condition, the separation yield of a target product can be up to approximately 95 percent.
PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 80, (2010/04/03)
The present invention relates to 2-pyridone derivatives of Formula (I) or (IV) as herein described, compositions containing such compounds, synthetic processes for making such compounds, and therapeutic methods that include the administration of such comp
Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists
Lai, Gaifa,Merritt, J. Robert,He, Zhenmin,Feng, Daming,Chao, Jianhua,Czarniecki, Michael F.,Rokosz, Laura L.,Stauffer, Tara M.,Rindgen, Diane,Taveras, Arthur G.
, p. 1864 - 1868 (2008/12/21)
A series of 3,4- and 3,5-disubstituted phenyl-containing cyclobutenedione analogues were synthesized and evaluated as CXCR2 receptor antagonists. Variations in the disubstitution pattern of the phenyl ring afforded new compounds with potent CXCR2 binding
ENANTIOMERICALLY PURE PHOSPHOINDOLES AS HIV INHIBITORS
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Page/Page column 133 - 134, (2008/06/13)
3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoi
Synthesis and characterization of aryl thioacetyl styrene monomers: towards a new generation of SERS-active polymers
Al-Hourani, Baker Jawabrah,Bravo-Vasquez, Juan P.,Hermann High,Fenniri, Hicham
, p. 9144 - 9147 (2008/09/17)
A new family of thioacetyl styrene derivatives was synthesized in good isolated yields for the preparation of spectroscopically-encoded SERS-active polymers.
META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS
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, (2008/06/13)
The present invention relates to a class of compounds represented by the Formula Ior a pharmaceutically acceptable salt thereof, whereinA ispharmaceutical compositions thereof and methods of using such compounds and compositions as alphavbeta3 antagonists.