188822-22-2Relevant articles and documents
Chiral Aryliodine-Catalyzed Asymmetric Oxidative C-N Bond Formation via Desymmetrization Strategy
Ding, Qiang,He, Huan,Cai, Qian
, p. 4554 - 4557 (2018)
An asymmetric oxidative C-N bond-forming reaction is developed using a chiral diiodospirobiindane derivative as the catalyst and mCPBA as a terminal oxidant. The protocol is based on an asymmetric desymmetrization strategy and affords lactams or spirolact
ACYLATED AMINO ACIDS AS ENDOTHELIN ANTAGONISTS
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, (2008/06/13)
Novel acylated amino acids which are antagonists of endothelin are described. Methods for their preparation and pharmaceutical compositions containing them are also included. The compounds are expected to be useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, diabetes, head injury, and stroke.