188824-29-5Relevant articles and documents
Synthesis and pharmacology of conformationally restricted raloxifene analogues: Highly potent selective estrogen receptor modulators
Grese, Timothy A.,Pennington, Lewis D.,Sluka, James P.,Dee Adrian,Cole, Harlan W.,Fuson, Tina R.,Magee, David E.,Lynn Phillips,Rowley, Ellen R.,Shetler, Pamela K.,Short, Lorri L.,Venugopalan, Murali,Yang, Na N.,Sato, Masahiko,Glasebrook, Andrew L.,Bryant, Henry U.
, p. 1272 - 1283 (1998)
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM) which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. In vivo structure- activity relationships and molecular