1888341-29-4

Upstream product

• 5188-07-8 sodium thiomethoxide 
• 1204669-65-7 2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl methanesulfonate 
• 1204669-64-6 4-(3-bromo-4-fluorophenyl)-3-{4-[(2-hydroxyethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one 
• 1204669-63-5 4-(3-bromo-4-fluorophenyl)-3-{4-[(2-methoxyethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one 
• 1204669-62-4 N-(3-bromo-4-fluorophenyl)-N‘-hydroxy-4-((2-methoxyethyl)amino)-1,2,5-oxadiazole-3-carboximidamide 
• 1204669-61-3 N-hydroxy-4-[(2-methoxyethyl)amino]-1,2,5-oxadiazole-3-carboximidoyl chloride 
• 1204669-60-2 N¹-hydroxy-4-((2-methoxyethyl)amino)-1,2,5-oxadiazole-3-carboximidamide 
• 1204669-59-9 4-amino-N‘-hydroxy-N-(2-methoxyethyl)-1,2,5-oxadiazole-3-carboximidamide 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1888378-12-8 (±)(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(S-methyl-S-cyanoiminosulfinyl)ethyl)amino)-1,2,5-oxadiazol-3-carboxamidine 

Relevant academic research and scientific papers

INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION

The present invention relates to an indoleamine 2,3-dioxygenase inhibitor having the structure of formula (I), a preparation method therefor, and an application. The IDO inhibitor is an N′-hydroxyl-N-phenylformamidine derivative, which has a high inhibito

Preparation method of indoleamine 2,3-dioxygenase inhibitor and intermediates thereof

The invention relates to a preparation method of an indoleamine 2,3-dioxygenase inhibitor and intermediates thereof. The invention discloses a preparation method capable of industrialization. By the method, problems of long synthetic route, low yield and unsuitable industrialization in the prior art are solved. The invention also relates to some intermediates for generating the indoleamine 2,3-dioxygenase inhibitor, especially an intermediate as shown in the general formula (I).

INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, ITS PREPARATION METHOD AND THE USE THEREOF

The present invention relates to Indoleamine 2,3-dioxygenase inhibitor represented by formula (I), its preparation method and the use thereof. The inhibitor of Indoleamine 2,3-dioxygenase (IDO for short) is the derivative of (Z)-N'-hydroxy-N-phenylformami

SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE

Provided are certain IDO inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Indoleamine-2, 3-dioxygenase inhibitor and preparation method thereof

The invention discloses an indoleamine-2, 3-dioxygenase inhibitor and a preparation method thereof. The inhibitor has a structural general formula I shown in the description. X, R1, R2, R3, R4, R7, R8, R9, n, m, and ring A are defined in the description and shown in the claims. The invention further discloses a preparation method of the inhibitor. The compound with the general formula I can be used as the indoleamine-2, 3-dioxygenase inhibitor, and is used for preparing a medicine for preventing and/or curing a disease mediated by indoleamine-2, 3-dioxygenase.