188837-53-8

Basic information

• Product Name: Pentafluorophenylpyridine-2-carBoxylate
• Synonyms: Pentafluorophenylpyridine-2-carBoxylate;Pentafluorophenyl pyridine-2-carboxylate 95%;Pentafluorophenylpyridine-2-carboxylate95%;Pentafluorophenyl pyridine-2-carboxylate, Pentafluorophenyl picolinate, 2-[(Pentafluorophenoxy)carbonyl]pyridine;Perfluorophenyl pyridine-2-carboxylate 95%;Perfluorophenylpyridine-2-carboxylate95%
• CAS NO: 188837-53-8
• Molecular Formula: C₁₂H₄F₅NO₂
• Molecular Weight: 289.16
• Mol File: 188837-53-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 55.5-59°C
• Boiling Point: 322.9°Cat760mmHg
• Flash Point: 149.1°C
• Appearance: /
• Density: 1.503g/cm³
• Vapor Pressure: 0.000271mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: Pentafluorophenylpyridine-2-carBoxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Pentafluorophenylpyridine-2-carBoxylate(188837-53-8)
• EPA Substance Registry System: Pentafluorophenylpyridine-2-carBoxylate(188837-53-8)

Safety Data

• Hazardous Substances Data: 188837-53-8(Hazardous Substances Data)

Usage

General Description

Pentafluorophenylpyridine-2-carboxylate is a chemical compound that belongs to the class of pyridine derivatives. It is a white to light yellow crystalline powder with a molecular formula of C12H5F5NO2. Pentafluorophenylpyridine-2-carBoxylate is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and material science. It is also utilized in organic synthesis as a coupling reagent for the preparation of complex organic molecules. Pentafluorophenylpyridine-2-carboxylate has the potential for various applications in the field of medicine, agriculture, and materials research due to its unique chemical properties and reactivity.

InChI:InChI=1/C7H4F2N4/c8-4-2-1-3-5(9)6(4)7-10-12-13-11-7/h1-3H,(H,10,11,12,13)

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 93-99-2 benzoic acid phenyl ester 
• 1057652-71-7 2,3,4,5,6-pentafluorophenyl 5-bromo-2-thiophenecarboxylate 
• 188837-55-0 pentafluorophenyl-furan-2-carboxylate 
• 158407-26-2 2,3,4,5,6-pentafluorophenyl 2-naphthoate 
• 1548-84-1 pentafluorophenyl benzoate 
• 166539-79-3 2,3,4,5,6-pentafluorophenyl 4-(trifluoromethyl)benzoate 
• 106159-22-2 2,3,4,5,6-pentafluorophenyl 4-chlorobenzoate 
• 187402-80-8 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate 
• 28078-88-8 4-nitrobenzoic acid pentafluorophenyl ester 
• 10354-53-7 N-phenylpicolinamide 

Relevant articles and documents

A simple method for synthesis of active esters of isonicotinic and picolinic acids

A method for preparation of the p-nitrophenyl-, N-hydroxysuccinimidyl- and pentafluorophenyl esters of isonicotinic and picolinic acids from the corresponding acids is reported.

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

A streamlined total synthesis of N14-desacetoxytubulysin H (Tb1) based on a C-H activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described. Applications of the developed synthetic strategies and technologies to the synthesis of a series of tubulysin analogues (Tb2-Tb41 and PTb-D42) are also reported. Biological evaluation of the synthesized compounds against an array of cancer cells revealed a number of novel analogues (e.g., Tb14), some with exceptional potencies against certain cell lines [e.g., Tb32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embryonic kidney) cell line], and a set of valuable structure-activity relationships. The highly potent cytotoxic compounds discovered in this study are highly desirable as payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies.

HERBICIDALLY ACTIVE 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS AND DERIVATIVES THEREOF

The present invention relates to a compound of formula (I): wherein the substituents are as defined herein, and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are thought to be suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.