188848-28-4

Basic information

• Product Name: Ethanone, 1-(5-methyl-2-thienyl)-2-(4-nitrophenyl)-
• CAS NO: 188848-28-4
• Molecular Formula: C13H11NO3S
• Molecular Weight: 261.301
• Mol File: 188848-28-4.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(5-methyl-2-thienyl)-2-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(5-methyl-2-thienyl)-2-(4-nitrophenyl)-(188848-28-4)
• EPA Substance Registry System: Ethanone, 1-(5-methyl-2-thienyl)-2-(4-nitrophenyl)-(188848-28-4)

Safety Data

• Hazardous Substances Data: 188848-28-4(Hazardous Substances Data)

Upstream product

• 554-14-3 2-Methylthiophene 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 104-03-0 4-nitrobenzeneacetic acid 

Downstream Products

• 188848-57-9 1-[1-(5-Methyl-thiophen-2-yl)-2-(4-nitro-phenyl)-ethyl]-1H-imidazole 
• 188848-42-2 1-(5-Methyl-thiophen-2-yl)-2-(4-nitro-phenyl)-ethanol 

Relevant articles and documents

Simple and efficient procedure for the friedel-crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/AL2O3 under heterogeneous conditions

An efficient and chemoselective method for the Friedel-Crafts acylation of aromatic compounds using P2O5/Al2O3 and carboxylic acids. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones in good yields.

Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 under heterogeneous conditions

A convenient and efficient procedure for the Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 is described. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.

Antifungal estrogen-like imidazoles. Synthesis and antifungal activities of thienyl and 1H-pyrrolyl derivatives of 1-aryl-2-(1H-imidazol-1-yl)ethane

Reaction of arylacetyl chlorides on thiophene or pyrrole derivatives furnished 2-aryl-1-(2-thienyl)- or 2-aryl-1-(1H-pyrrol-2-yl)-1-ethanones. Reduction of ketones to the corresponding carbinols and reaction of the latter compounds with 1,1'-sulfonyldiimidazole or 1,1'-carbonyldiimidazole gave 2-thienyl- and 1H-pyrrol-2-yl-1-aryl-2-(1H-imidazol-1-yl)ethanes, respectively. The new compounds were tested in vitro against a variety of pathogenic fungi in comparison with miconazole and bifonazole. Some a 5-chloro-2-thienyl derivatives were endowed with good antifungal activity, particularly against Candida albicans and Cryptococcus neoformans.