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2-hydroxyhexahydro-1H-isoindole-1,3(2H)-dione, commonly known as alitame, is a synthetic low-calorie sweetener that is approximately 2000 times sweeter than sucrose. It is characterized by its stability at high temperatures and across a broad pH range, which makes it an ideal sugar substitute for various food and beverage applications.

18886-85-6

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18886-85-6 Usage

Uses

Used in Food and Beverage Industry:
2-hydroxyhexahydro-1H-isoindole-1,3(2H)-dione is used as a sugar substitute for its intense sweetness in food and beverage products, offering a low-calorie alternative to traditional sugar. Its stability in high temperatures and wide pH levels makes it suitable for a range of applications, from baked goods to soft drinks.
Used in Health and Diet Products:
In the health and diet industry, 2-hydroxyhexahydro-1H-isoindole-1,3(2H)-dione is utilized as a sweetening agent in products designed for weight management and diabetes management, due to its low-calorie content and minimal impact on blood sugar levels.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, given its properties, 2-hydroxyhexahydro-1H-isoindole-1,3(2H)-dione could potentially be used in the pharmaceutical industry for the development of sugar-free medications or as an ingredient in oral health products, capitalizing on its non-caloric sweetness and stability.

Check Digit Verification of cas no

The CAS Registry Mumber 18886-85-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,8 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18886-85:
(7*1)+(6*8)+(5*8)+(4*8)+(3*6)+(2*8)+(1*5)=166
166 % 10 = 6
So 18886-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H11NO3/c10-7-5-3-1-2-4-6(5)8(11)9(7)12/h5-6,12H,1-4H2

18886-85-6Relevant academic research and scientific papers

Production method for diazabicyclooctane derivative and intermediary body thereof

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Paragraph 0561; 0562; 0563; 0564; 0565; 0566, (2016/10/08)

The present invention provides a production method for a diazabicyclooctane derivative expressed by formula (IV), and an intermediary body thereof (in the formula: P is an acid-removable NH protective group; R1 represents a 2, 5-dioxopyrrolidine-1-yl, a 1, 3-dioxo-3a, a 4, 7, 7a-tetrahydro-1H-isoindole-2(3H)-yl, a 1, 3-dioxohexahydro-1H-isoindole-2(3H)-yl, or a 3, 5-dioxo-4-azatricyclo[5.2.1.02, 6]deca-8-en-4-yl; R2 represents hydrogen, C1CO-, or C13COCO-, R3 represents a C1-6 alkyl or a heterocyclyl, or joins with a bonded -O-NH- to form a 3-7 member heterocyclyl ring; and OBn represents a benzyloxy).

CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVE AND PRODUCTION PROCESS THEREOF

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Paragraph 0325; 0326; 0327, (2016/10/11)

A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same:

CRYSTAL OF DIAZABICYCLEOCTANE DERIVATE AND METHOD FOR PRODUCING THE SAME

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Paragraph 0177, (2017/02/02)

The present invention provides a crystal of diazabicycleoctane derivate represented by the following formula (VII), especially formula (VII-1), and a method for producing the same.

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