188881-92-7Relevant articles and documents
The titanocene-catalyzed reduction of acetamides to tertiary amines by PhMeSiH2
Selvakumar, Kumaravel,Rangareddy, Kesamreddy,Harrod, John F.
, p. 1244 - 1248 (2004)
A variety of acetamide derivatives are reduced in excellent yields to tertiary amines by PhMeSiH2 in the presence of Cp2TiX 2 (X = F or Me) catalysts. The reactions are very clean at 80 °C. At room temperature a secondary reaction, hydrogenolysis of the C(O)-N bond, intervenes and reduces the chemoselectivity. Nevertheless, this chemistry provides a simple methodology for the amide/alkylamine transformation using inexpensive, commercially available reagents.