(CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN) is a cyclized form of parathyroid hormone (PTH) derived from the parathyroid gland. It is composed of amino acids 1 to 31 with an amide group at the C-terminus. This peptide hormone is essential for regulating calcium and phosphate levels in the blood by acting on bone, kidney, and intestine, thereby maintaining bone health and overall calcium metabolism.
188899-65-2
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Basic information
- Product Name: (CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN)
- Synonyms: H-SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-CYCLO(GAMMA-GLU-TRP-LEU-ARG-EPSILON-LYS)-LEU-LEU-GLN-ASP-VAL-NH2 (CYCLIZED BETWEEN GAMMA-GLU22 AND EPSILON-LYS26);(LEU27)-PTH (1-31) AMIDE (HUMAN);(CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN);H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-cyclo(-Glu-Trp-Leu-Arg-Lys)-Leu-Leu-Gln-Asp-Val-NH2;(Cyclo(Glu22-Lys2),Leu2)-pTH (1-31) amide (human)
- CAS NO:188899-65-2
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -15°C
- Solubility: N/A
- CAS DataBase Reference: (CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN)(CAS DataBase Reference)
- NIST Chemistry Reference: (CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN)(188899-65-2)
- EPA Substance Registry System: (CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN)(188899-65-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 188899-65-2(Hazardous Substances Data)
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188899-65-2 Usage
Uses
Used in Pharmaceutical Industry:(CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN) is used as a therapeutic agent for the treatment of conditions related to calcium and phosphate metabolism, such as hypocalcemia and osteoporosis. It is used to stimulate the release of calcium from bone, enhance calcium reabsorption in the kidneys, and promote calcium absorption in the intestine, thereby correcting calcium imbalances in the body.
Used in Research Applications:
(CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN) is used as a research tool for studying the mechanisms of calcium and phosphate regulation in the body. It helps researchers understand the role of PTH in bone metabolism, kidney function, and intestinal absorption, providing insights into the development of new therapeutic strategies for related diseases.
Used in Diagnostic Applications:
(CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN) can be used as a diagnostic marker to assess the levels of PTH in the blood, which can indicate the presence of conditions related to calcium and phosphate metabolism. This helps in the early detection and monitoring of diseases such as hyperparathyroidism and hypoparathyroidism.
Check Digit Verification of cas no
The CAS Registry Mumber 188899-65-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,8,9 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.Calculate Digit Verification of CAS Registry Number 188899-65:
(8*1)+(7*8)+(6*8)+(5*8)+(4*9)+(3*9)+(2*6)+(1*5)=232
232 % 10 = 2
So 188899-65-2 is a valid CAS Registry Number.
188899-65-2Upstream product
188899-65-2Downstream Products
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(CYCLO (GLU22-LYS26),LEU27)-PTH (1-31) AMIDE (HUMAN)
