188909-48-0

Basic information

• Product Name: 2-Oxazolidinone, 4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-phenyl-3-(phenylmethoxy)-, (4R)-
• CAS NO: 188909-48-0
• Molecular Formula: C21H23NO5
• Molecular Weight: 369.417
• Mol File: 188909-48-0.mol

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-phenyl-3-(phenylmethoxy)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-phenyl-3-(phenylmethoxy)-, (4R)-(188909-48-0)
• EPA Substance Registry System: 2-Oxazolidinone, 4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-phenyl-3-(phenylmethoxy)-, (4R)-(188909-48-0)

Safety Data

• Hazardous Substances Data: 188909-48-0(Hazardous Substances Data)

Upstream product

• 188909-37-7 O-Benzyl-N-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-phenyl-ethyl]-hydroxylamine 
• 188909-26-4 2-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone O-benzyl-oxime 
• 188909-23-1 2-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone O-benzyl-oxime 
• 622-33-3 N-benzyloxyamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 211044-94-9 (2R,3R)-3,4-O-isopropylidene-2-(N-benzyloxyamino)-2-phenylbutane-1,3,4-triol 

Downstream Products

• 6321-86-4 (R)-α-phenylserine 
• 188909-53-7 (2R)-3-hydroxy-2-(N-benzyloxyamino)-2-phenylpropionic acid 
• 188909-50-4 (4R)-3-benzyloxy-4-phenyl-4-methoxycarbonyl-1,3-oxazolidin-2-one 
• 211188-24-8 (4R)-3-benzyloxy-4-phenyl-4-((1R)-1,2-dihydroxyethyl)-1,3-oxazolidin-2-one 

Relevant articles and documents

Stereoselective synthesis of α-substituted serines from protected erythrulose oximes

The additions of organolithium reagents to the C=N bond of several chiral oxime ethers derived from erythrulose afforded protected amino polyols with high diastereoselectivity. Four of the latter compounds have been convened into the α,α-disubstituted α-amino acids (R)-2-(-)-methylserine, (S)-2-(+)-methylserine, (R)-(+)-2-phenylserine and (R)-(-)-2-n-butylserine.

Diastereoselective additions of organolithium reagents to the C=N bond of protected erythrulose oxime ethers. Synthesis of enantiopure α,α-disubstituted α-aminoacids

The addition of organolithium reagents to the C=N bond of several erythrulose-derived chiral (E)- and (Z)-ketoxime ethers has been shown to be highly diastereoselective for the (E)-isomers. A chelated transition state has been proposed to explain this result. The addition products were converted into the two α,α-disubstituted α-aminoacids (R)-2-(-)-methylserine and (R)-(+)-2-phenylserine.