188923-19-5

Basic information

• Product Name: 1,3-Dioxepan-5-ol, 2,2-dimethyl-6-[[(1R)-1-phenylethyl]amino]-, (5R,6S)-
• CAS NO: 188923-19-5
• Molecular Formula: C15H23NO3
• Molecular Weight: 265.353
• Mol File: 188923-19-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxepan-5-ol, 2,2-dimethyl-6-[[(1R)-1-phenylethyl]amino]-, (5R,6S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxepan-5-ol, 2,2-dimethyl-6-[[(1R)-1-phenylethyl]amino]-, (5R,6S)-(188923-19-5)
• EPA Substance Registry System: 1,3-Dioxepan-5-ol, 2,2-dimethyl-6-[[(1R)-1-phenylethyl]amino]-, (5R,6S)-(188923-19-5)

Safety Data

• Hazardous Substances Data: 188923-19-5(Hazardous Substances Data)

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 100572-41-6 4,4-dimethyl-3,5,8-trioxa-bicyclo-[5.1.0]octane 

Downstream Products

• 188923-21-9 (5R,6S)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol acetate 

Relevant articles and documents

Process for producing amide derivatives and intermediates therefor

PCT No. PCT/JP96/02756 Sec. 371 Date Apr. 14, 1998 Sec. 102(e) Date Apr. 14, 1998 PCT Filed Sep. 24, 1996 PCT Pub. No. WO97/11937 PCT Pub. Date Apr. 3, 1997A method for producing an amide derivative of the formula [XV] wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.

A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-l,3-dioxepan-6-ylammonium Acetate

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