188927-53-9

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 6-methoxy-5-(1-methylethoxy)-3-[[(4-methylphenyl)sulfonyl]oxy]-7-(phenyl methoxy)-2-[4-(phenylmethoxy)phenyl]-
• CAS NO: 188927-53-9
• Molecular Formula: C40H36O9S
• Molecular Weight: 692.786
• Mol File: 188927-53-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 6-methoxy-5-(1-methylethoxy)-3-[[(4-methylphenyl)sulfonyl]oxy]-7-(phenyl methoxy)-2-[4-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 6-methoxy-5-(1-methylethoxy)-3-[[(4-methylphenyl)sulfonyl]oxy]-7-(phenyl methoxy)-2-[4-(phenylmethoxy)phenyl]-(188927-53-9)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 6-methoxy-5-(1-methylethoxy)-3-[[(4-methylphenyl)sulfonyl]oxy]-7-(phenyl methoxy)-2-[4-(phenylmethoxy)phenyl]-(188927-53-9)

Safety Data

• Hazardous Substances Data: 188927-53-9(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 188927-38-0 7-Benzyloxy-2-(4-benzyloxy-phenyl)-3-hydroxy-5-isopropoxy-6-methoxy-chromen-4-one 
• 1486-50-6 4-(benzyloxy)benzoic acid chloride 
• 3162-51-4 1-(2,4-Bis-benzyloxy-3,6-dimethoxy-phenyl)-ethanone 
• 3162-52-5 1-(4-benzyloxy-2-hydroxy-3,6-dimethoxy-phenyl)-ethanone 
• 7499-99-2 1-(2,4-dihydroxy-3,6-dimethoxy)phenylethanone 
• 188927-31-3 4-benzyloxy-6-hydroxy-3-methoxy-2-isopropoxyacetophenone 
• 188927-62-0 1-(4-Benzyloxy-2-isopropoxy-3,6-dimethoxy-phenyl)-ethanone 
• 1026154-00-6 4-Benzyloxy-benzoic acid 2-acetyl-5-benzyloxy-3-isopropoxy-4-methoxy-phenyl ester 
• 188927-48-2 7-Benzyloxy-2-(4-benzyloxy-phenyl)-5-isopropoxy-6-methoxy-chromen-4-one 
• 100-44-7 benzyl chloride 

Downstream Products

• 188927-58-4 7-Benzyloxy-2-(4-benzyloxy-phenyl)-3,5-dihydroxy-6-methoxy-chromen-4-one 
• 32557-95-2 3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-6-methoxy-chromen-4-one 
• 32520-55-1 6-methoxykaempferol 
• 188927-43-7 Toluene-4-sulfonic acid 7-benzyloxy-2-(4-benzyloxy-phenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-3-yl ester 

Relevant articles and documents

Studies of the selective O-alkylation and dealkylation of flavonoids. XXII. A convenient method for synthesizing 3,5,7-trihydroxy-6-methoxyflavones

The demethylation of 3,4-dioxygenated 6-methoxy-2- isopropoxyacetophenones was studied and it was found that 4-benzyloxy-6- hydroxy-3-methoxy-2-isopropoxyacetophenone was easily obtained from 4- benzyloxy-3,6-dimethoxy-2-isopropoxyacetophenone by selective demethylation with anhydrous aluminum bromide-sodium iodide in acetonitrile. The acetophenone was converted into 7-benzyloxy-3-hydroxy-6-methoxy-5- isopropoxyflavones by cyclization followed by oxidation with dimethyldioxirane. The isopropoxy group in the flavones was selectively cleaved with anhydrous aluminum chloride via the corresponding tosylates to give 7-benzyloxy-3,5-dihydroxy-6-methoxyflavones, which were converted into the desired 3,5,7-trihydroxy-6-methoxyflavones by hydrogenolysis. The process was suitable as a general method for synthesizing 3,5,7-trihydroxy-6- methoxyflavones and five flavones were synthesized. We also examined the 13C-NMR spectra of twelve kinds of 3,5,6,7-tetraoxygenated 4'- methoxyflavones and revised the proposed structure of a natural flavone.