188937-72-6

Basic information

• Product Name: 2(1H)-Pyrimidinone, 5-benzoyl-4-(trifluoromethyl)-, 2-hydrazone
• CAS NO: 188937-72-6
• Molecular Formula: C12H9F3N4O
• Molecular Weight: 282.225
• Mol File: 188937-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrimidinone, 5-benzoyl-4-(trifluoromethyl)-, 2-hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 5-benzoyl-4-(trifluoromethyl)-, 2-hydrazone(188937-72-6)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 5-benzoyl-4-(trifluoromethyl)-, 2-hydrazone(188937-72-6)

Safety Data

• Hazardous Substances Data: 188937-72-6(Hazardous Substances Data)

Upstream product

• 149771-17-5 2-Methylsulfanyl-4-trifluoromethyl-pyrimidine-5-carboxylic acid 
• 235429-39-7 (2-methanesulfonyl-4-trifluoromethyl-pyrimidin-5-yl)-phenyl-methanone 

Relevant articles and documents

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate: An inhibitor of AP-1 and NF-κB mediated gene expression

Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-κB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)- pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.