18895-94-8

Basic information

• Product Name: 2-Pyridinecarboximidic acid, 6-methyl-, hydrazide
• Synonyms: 2-Pyridinecarboximidic acid, 6-methyl-, hydrazide;6-Methylpyridine-2-carbohydrazonamide
• CAS NO: 18895-94-8
• Molecular Formula: C₇H₁₀N₄
• Molecular Weight: 150.18
• Mol File: 18895-94-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 115-116 °C(Solv: ethanol (64-17-5))
• Boiling Point: 274.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 7.53±0.50(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboximidic acid, 6-methyl-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboximidic acid, 6-methyl-, hydrazide(18895-94-8)
• EPA Substance Registry System: 2-Pyridinecarboximidic acid, 6-methyl-, hydrazide(18895-94-8)

Safety Data

• Hazardous Substances Data: 18895-94-8(Hazardous Substances Data)

Upstream product

• 1620-75-3 2-Cyano-6-methylpyridine 

Downstream Products

• 18895-96-0 3-(6-methylpyridin-2-yl)-5,6-diphenyl-1,2,4-triazine 
• 1416475-30-3 6-(5,6-diphenyl-1,2,4-triazin-3-yl)-2-picolinic acid 
• 1416475-29-0 C₂₁H₁₄N₄O 
• 1416475-31-4 C₂₉H₃₁N₅O 

Relevant articles and documents

Pd-Catalyzed Diamination of 1,2,4-Triazinyl Complexant Scaffolds

As part of ongoing efforts in this laboratory to design and synthesize multidentate soft-N-donors as effective complexants for chemoselective minor actinide extraction from used nuclear fuel, a series of aminated mono-1,2,4-triazinylpyridines were require

1,2,4-Triazine-picolinamide functionalized, nonadentate chelates for the segregation of lanthanides(iii) and actinides(iii) in biphasic systems

A novel family of nonadentate ligands based on the (5,6-diphenyl-1,2,4- triazin-3-yl)-picolinamide donor moiety has been synthesized from simple starting materials in high yield and purity. This group of ligands is an addition to the neutral nonadentate group but the first to incorporate 1,2,4-triazine. Their ability to extract a select group of lanthanides from acidic aqueous solution has been correlated to their ability to meet the ideal trigonal tricapped prismatic geometry that is seen by lanthanides and actinides in aqueous solution. The rate of metallation was determined using UV/VIS spectroscopy with pseudo first order conditions and showed similar behaviour to literature examples. Theoretical calculations were used to probe the bonding structure with lanthanides and actinides to predict the potential Ln/An segregating ability of the new ligands.

FUSED PYRIMIDINES AS AKT INHIBITORS

The present invention relates to compounds of formula (I), a N-oxide or tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6, R7, R10, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.