188957-39-3

Upstream product

• 188957-33-7 (1Z,6E)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3,7,11-trimethyl-dodeca-1,6,10-trien-3-ol 
• 626-02-8 3-Iodophenol 
• 133910-12-0 (1,1-dimethylethyl)(3-iodophenoxy)dimethylsilane 
• 188957-27-9 (E)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3,7,11-trimethyl-dodeca-6,10-dien-1-yn-3-ol 
• 59905-15-6 dehydronerolidol 
• 3879-26-3 (Z)-nerylacetone 

Relevant academic research and scientific papers

The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

(Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Δ3,4-chromenes the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring.