18896-84-9

Upstream product

• 129528-98-9 bis(4-methylbenzyl)phosphine oxide 
• 104-82-5 4-Methylbenzyl chloride 
• 104-81-4 4-Methylbenzyl bromide 

Downstream Products

• 129554-59-2 bis(4-methylbenzyl)phosphinic amide 
• 129529-06-2 methyl bis(4-methylbenzyl)phosphinate 
• 129528-99-0 N-hydroxylamine 
• 129529-04-0 ethyl bis(4-methylbenzyl)phosphinate 
• 129529-03-9 isopropyl bis(4-methylbenzyl)phosphinate 
• 129529-02-8 N-methoxy bis(4-methylbenzyl)phosphinic amide 
• 129529-13-1 t-butyl bis(4-methylbenzyl)phosphinate 
• 129529-01-7 N--N'-t-butylhydrazine 
• 129529-10-8 t-butyl N,P-bis(4-methylbenzyl)phosphonamidate 
• 129529-00-6 N--O-methylsulphonylhydroxylamine 
• 129529-12-0 sodium bis(4-methylbenzyl)phosphinate 

Relevant academic research and scientific papers

Golden Face of Phosphine: Cascade Reaction to Bridgehead Methanophosphocines by Intramolecular Double Hydroarylation

Reported herein is the first example of a gold-catalyzed cyclization of bis(arylmethyl)ethynylphosphine oxides. This represents an original approach to bridgehead methanophosphocines 1, eight-membered heterocycles. Gold catalyst in combination with triflic acid activates alkyne and induces a double hydroarylation. Mechanistic studies suggest that the reaction proceeds stepwise, forming first the 1H-isophosphinoline 2-oxide 5. Reduction and protection of the corresponding phosphine oxides 1 described herein also highlight the effectiveness of our approach to this new class of electron-rich ligands.

Migration of a Benzyl group in the Lossen-like Rearrangement of an N-Phosphinoyl-O-sulphonylhydroxylamine

Migration of a group other than aryl has been observed for the first time in the Lossen-like rearrangement of an N-phosphinoyl-O-sulphonylhydroxylamine: the benzylic substrate (ArCH2)2P(O)NHOMs (Ar= p-tolyl) gives the phosphonamidate ArCH2P(O)(OR)NHCH2Ar