188970-78-7 Usage
Uses
Used in Environmental Monitoring and Control:
5-nitro-7H-dibenzo[c,g]carbazole is used as a biomarker for monitoring and controlling environmental pollution levels. Its presence in various pollutants, such as cigarette smoke, automobile exhaust, and industrial emissions, allows for the assessment of exposure risks and the implementation of measures to reduce human exposure to this hazardous compound.
Used in Toxicological Research:
5-nitro-7H-dibenzo[c,g]carbazole serves as a valuable compound in toxicological research, particularly in the study of mutagenicity and carcinogenicity. Its potent mutagenic properties and association with an increased risk of cancer make it an important subject for understanding the mechanisms of chemical-induced genetic mutations and cancer development.
Used in Regulatory Compliance and Policy Development:
5-nitro-7H-dibenzo[c,g]carbazole is utilized in the development of regulatory compliance standards and policies aimed at minimizing human exposure to this hazardous compound. By establishing permissible exposure limits and implementing strategies to reduce environmental levels of N-7D, regulatory bodies can help protect public health and reduce the incidence of cancer related to exposure to this potent mutagen and carcinogen.
Used in Public Health Education and Awareness:
5-nitro-7H-dibenzo[c,g]carbazole plays a role in public health education and awareness campaigns, informing individuals about the potential risks associated with exposure to this hazardous compound. By raising awareness about the sources of N-7D and the health implications of exposure, public health initiatives can encourage individuals to take preventive measures and advocate for policies that reduce environmental levels of this potent mutagen and carcinogen.
Used in Industrial Process Improvement:
5-nitro-7H-dibenzo[c,g]carbazole is employed in the evaluation and improvement of industrial processes to minimize the release of this hazardous compound into the environment. By identifying and addressing the sources of N-7D in industrial emissions, companies can implement cleaner production methods and reduce the environmental impact of their operations, contributing to the overall reduction of human exposure to this potent mutagen and carcinogen.
Check Digit Verification of cas no
The CAS Registry Mumber 188970-78-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,9,7 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 188970-78:
(8*1)+(7*8)+(6*8)+(5*9)+(4*7)+(3*0)+(2*7)+(1*8)=207
207 % 10 = 7
So 188970-78-7 is a valid CAS Registry Number.
188970-78-7Relevant academic research and scientific papers
Synthesis, characterization, and mutagenicity of nitrated 7H- dibenzo[c,g]carbazole and its phenolic derivatives
Xue, Weiling,LaDow, Kathleen,Warshawsky, David
, p. 432 - 438 (2007/10/03)
The nitrated N-heterocyclic aromatic hydrocarbons (NAHs) are found in a variety of environmental sources; many of them have been determined to be mutagenic in short-term assays and/or carcinogenic in animal tests. In this laboratory, we synthesized and characterized nitrated 7H- dibenzo[c,g]carbazole (DBC) and the nitrophenolic metabolites of DBC as potential mutagenic and carcinogenic xenobiotics. The nitro group was formed exclusively at the 5 and/or the symmetric 9 position of DBC, 2-hydroxy-DBC, 3-hydroxy-DBC, and 4-hydroxy-DBC. Ames plate incorporation mutagenicity assays were conducted using Salmonella typhimurium strains TA98 and TA100, with or without rat liver homogenates (S9). Mutagenicities of the nitrated DBCs were higher than the parent DBC in strain TA98. 5,9-Dinitro-DBC had stronger mutagenic responses than 5-nitro-DBC in all assays, particularly in strain TA98 with S9. 5,9-Dinitro-DBC had a higher reduction potential relative to 5-nitro-DBC (-1.09 V and -1.37 V, respectively). Hydroxyl derivatives of 5-nitro-DBC at the 2, 3, 4, 10, or 12 position, synthesized through nitration of the corresponding hydroxy-DBC, possessed greater mutagenicity than the parent 5-nitro-DBC, especially in strain TA100 with or without S9. Our data suggest that nitrated DBC undergoes both nitroreduction and ring oxidation as the primary pathways for the metabolic activation leading to mutagenesis. The relative mutagenicities of the nitrohydroxy-DBC isomers are generally consistent with the resonance stabilization of the positive charge at the arylnitrenium ion, formed from the nitro functional group, as the proposed active electrophile responsible for genotoxic effects.
