188978-98-5Relevant academic research and scientific papers
Synthesis and characterization of photolabile compounds releasing noracetylcholine in the microsecond time range
Peng,Wirz,Goeldner
, p. 398 - 400 (2007/10/03)
The rapid and efficient photochemical release of noracetylcholine 2, an analogue of the neurotransmitter acetylcholine, from its precursor 1 makes this probe well-suited for a dynamic study of the mechanism of hydrolysis of acetylcholine by acetylcholinesterase. The nitrobenzyl derivative 1, the most promising candidate for time-resolved crystallographic studies of this rapid enzyme, displays the required photo-fragmentation kinetics in the microsecond time-range and inhibitory properties oacetylcholinesterase.
2-Nitrobenzyl quaternary ammonium derivatives photoreleasing nor-butyrylcholine in the microsecond time range
Peng, Ling,Wirz, Jakob,Goeldner, Maurice
, p. 2961 - 2964 (2007/10/03)
2-Nitrobenzyl derivatives of nor-butyrylcholine (N,N-dimethylaminoethyl butyrate) were synthesized and characterized as photolabile inhibitors of butyrylcholinesterase, displaying the required photofragmentation kinetics for rapid release of the enzyme substrate, nor-butyrylcholine.
