188981-81-9

Upstream product

• 179749-34-9 Cyclohexa-2,5-dienyl-dimethyl-silanol 
• 188981-72-8 [(1S,2S,6S)-6-Hydroxy-2-(hydroxy-dimethyl-silanyl)-cyclohex-3-enyl]-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Asymmetric amino-hydroxylation of dienylsilanes. An efficient route to amino-cyclitols

Sharpless asymmetric amino-hydroxylation of a silyl-2,5-cyclohexadiene occurs with complete regio- and diastereocontrol. An enantioselectivity of up to 68% e.e. was also observed. An application of the methodology to the synthesis of relevant examples of amino-cyclitols is described.