188999-61-3

Basic information

• Product Name: Benzenemethanaminium, N,N,N-triethyl-3-formyl-4-hydroxy-, chloride
• CAS NO: 188999-61-3
• Molecular Formula: C14H22NO2.Cl
• Molecular Weight: 271.787
• Mol File: 188999-61-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanaminium, N,N,N-triethyl-3-formyl-4-hydroxy-, chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanaminium, N,N,N-triethyl-3-formyl-4-hydroxy-, chloride(188999-61-3)
• EPA Substance Registry System: Benzenemethanaminium, N,N,N-triethyl-3-formyl-4-hydroxy-, chloride(188999-61-3)

Safety Data

• Hazardous Substances Data: 188999-61-3(Hazardous Substances Data)

Usage

Molecular Weight

289.81 g/mol

Primary Use

Intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds

Properties

Quaternary ammonium compound

Usage

Organic synthesis, catalyst in chemical reactions

Special Properties

Facilitates formation of carbon-carbon bonds, potential anti-inflammatory and antioxidant effects

Industry

Widely used in pharmaceutical industry for drug production.

Upstream product

• 23731-06-8 5-(chloromethyl)salicylaldehyde 
• 121-44-8 triethylamine 
• 90-02-8 salicylaldehyde 

Relevant articles and documents

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes

Novel nickel(II) (1) and zinc(II) (2) complexes of a Salen-like ligand, carrying a pyrimidine ring on the N,N′ bridge, were synthesized and characterized. Their interaction with duplex and G-quadruplex DNA was investigated in aqueous solution through UV-visible absorption, circular dichroism and viscometry measurements. The results obtained point out that, while the zinc(II) complex does not interact with both duplex and G-quadruplex DNA, the nickel(II) complex 1 binds preferentially to G-quadruplex respect to duplex-DNA, with values of the DNA-binding constants, Kb, 2.6 × 105 M- 1 and 3.5 × 104 M- 1, respectively. Molecular dynamics simulations provided an atomic level model of the top-stacking binding occurring between 1 and hTelo (a 22-mer sequence oligonucleotide) in G-quadruplex conformation.

Fluorescence emission and enhanced photochemical stability of ZnII-5-triethyl ammonium methyl salicylidene ortho-phenylendiiminate interacting with native DNA

The photophysical and photochemical properties of the cationic ZnII complex of 5-triethyl ammonium methyl salicylidene ortho-phenylendiimine (ZnL2+) interacting with native DNA were investigated by steady state and time-resolved fluo

Synthesis of New Cationic Schiff Base Complexes of Copper(II) and Their Selective Binding with DNA

A series of cationic salen-type Schiff base complexes of copper(II), the general formula of which is [Cu{R3N+-CH2-C6H3(O -)-CH=N-}2X]Br2 (R: CH3, C2H5, C3H7, C4H9; X: C2H4, C3H6, C6H10, C6H4, C10H6), was newly prepared, and the molecular structure of complex 1 (R=CH3, X=C2H4) was determined by an X-ray crystal structure analysis. The binding mode and binding constants (Kb) of all the complexes with calf thymus DNA were investigated at an ionic strength of I = 0.05 (NaCl + HEPES buffer, pH = 7.2) using induced CD and the UV-vis spectra. Those complexes with aliphatic X group selectively bound to the groove of DNA, and the Kb's were in the range of 102 - 103 mol dm-3 (site size base pairs n = 7.2 - 7.4). However, those with aromatic X group selectivity intercalated to the base pairs, and the Kb's were in the range of 104 - 105 mol dm-3 (n = 2.8 - 4.0). These binding modes were confirmed based on the salt dependence of Kb's. In addition, 1 and 10 (R = CH3, X = C6H4) were found to exhibit AT-sequence affinity from the induced CD spectra and Kb's for poly(dA-dT)-poly(dA-dT), poly(dG-dC)-poly(dG-dC), and poly(dA-dC)-poly(dT-dG).