189003-92-7

Basic information

• Product Name: 2-{7-FLUORO-2-OXO-4-[2-(4-THIENO[3,2-C]PYRIDIN-4-YLPIPERAZIN-1-YL)ETHYL]QUINOLIN-1(2H)-YL}ACETAMIDE
• Synonyms: 2-{7-FLUORO-2-OXO-4-[2-(4-THIENO[3,2-C]PYRIDIN-4-YLPIPERAZIN-1-YL)ETHYL]QUINOLIN-1(2H)-YL}ACETAMIDE;1(2H)-QuinolineacetaMide,7-fluoro-2-oxo-4-[2-(4-thieno[3,2-c]pyridin-4-yl-1-piperazinyl)ethyl]-;SL 650472;Trelanserin;2-[7-fluoro-2-oxo-4-[2-(4-thieno[3,2-c]pyridin-4-ylpiperazin-1-yl)ethyl]quinolin-1-yl]acetamide
• CAS NO: 189003-92-7
• Molecular Formula: C24H24 F N5 O2 S
• Molecular Weight: 465.54
• Mol File: 189003-92-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 703.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.365±0.06 g/cm3(Predicted)
• PKA: 15.57±0.40(Predicted)
• CAS DataBase Reference: 2-{7-FLUORO-2-OXO-4-[2-(4-THIENO[3,2-C]PYRIDIN-4-YLPIPERAZIN-1-YL)ETHYL]QUINOLIN-1(2H)-YL}ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{7-FLUORO-2-OXO-4-[2-(4-THIENO[3,2-C]PYRIDIN-4-YLPIPERAZIN-1-YL)ETHYL]QUINOLIN-1(2H)-YL}ACETAMIDE(189003-92-7)
• EPA Substance Registry System: 2-{7-FLUORO-2-OXO-4-[2-(4-THIENO[3,2-C]PYRIDIN-4-YLPIPERAZIN-1-YL)ETHYL]QUINOLIN-1(2H)-YL}ACETAMIDE(189003-92-7)

Safety Data

• Hazardous Substances Data: 189003-92-7(Hazardous Substances Data)

Usage

Structural Components

Fluorine atom
Quinoline ring
Piperazine ring
Thieno[3,2-c]pyridine ring
Acetamide functional group
Ketone group

Synthesis

Chemically synthesized in laboratory settings.

Medicinal Chemistry Application

Utilized as a potential drug candidate.

Pharmacological Activities

Subject to further research and development to determine specific properties and potential uses in pharmaceuticals.

Upstream product

• 79-07-2 Chloroacetamide 
• 189003-71-2 7-fluoro-4-[2-[4-(thieno[3,2-c]pyridin-4-yl)piperazin-1-yl]ethyl]quinolin-2(1H)-one 
• 130133-31-2 methyl 7-fluoro-2-oxo-1,2-dihydro-4-quinolineacetate 
• 130133-30-1 7-Fluoro-2-oxo-1,2-dihydro-4-quinolineacetic acid 
• 130133-32-3 7-Fluoro-4-(2-hydroxyethyl)-2(1H)-quinolinone 
• 130133-33-4 4-(2-Chloroethyl)-7-fluoro-2(1H)-quinolinone 
• 372-19-0 meta-fluoroaniline 
• 15997-62-3 2,6-dioxo-3,6-dihydro-2H-pyran-4-yl acetate 
• 683-57-8 bromo-acetic acid amide 

Relevant articles and documents

Synthesis and SAR of 3- and 4-substituted quinolin-2-ones: Discovery of mixed 5-HT1B/5-HT2A receptor antagonists

Quinolin-2-ones bearing a heteroaryl-piperazine linked by a two carbon chain at the 3- or 4-position were synthesised and evaluated as mixed 5-HT1B/5-HT2A receptor antagonists. Potent mixed antagonists were obtained with thieno[3,2-c]pyridine derivatives. In this series, compound 2.1 (SL 65.0472) proved to be functional antagonist at both the 5-HT2A receptor (rat in vivo 5-HT-induced hypertension model) and the 5-HT1B receptor (dog in vitro saphenous vein assay).

QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS

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