18903-04-3

Basic information

• Product Name: Piperazine, 1-(1-oxobutyl)- (9CI)
• Synonyms: Piperazine, 1-(1-oxobutyl)- (9CI);1-BUTANOYLPIPERAZINE;1-Butanone, 1-(1-piperazinyl)-
• CAS NO: 18903-04-3
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.22544
• Product Categories: PIPERIDINE
• Mol File: 18903-04-3.mol

Chemical Properties

• Boiling Point: 286.5±33.0 °C(Predicted)
• Appearance: /
• Density: 0.989±0.06 g/cm3(Predicted)
• PKA: 8.48±0.10(Predicted)
• CAS DataBase Reference: Piperazine, 1-(1-oxobutyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(1-oxobutyl)- (9CI)(18903-04-3)
• EPA Substance Registry System: Piperazine, 1-(1-oxobutyl)- (9CI)(18903-04-3)

Safety Data

• Hazardous Substances Data: 18903-04-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine, 1-(1-oxobutyl)(9CI) is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Anti-Tumor Evaluation:
In the field of anti-tumor research, Piperazine, 1-(1-oxobutyl)(9CI) has been utilized in the preparation of triazolotetrazine derivatives. These derivatives are evaluated for their potential anti-tumor properties, with the aim of developing new and effective treatments for cancer.

Upstream product

• 110-85-0 piperazine 
• 107-92-6 butyric acid 
• 314728-81-9 4-benzyl-1-butyrylpiperazine 

Relevant articles and documents

New antiproliferative benzoindolinothiazepines derivatives

New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.

Direct synthesis of N-acylalkylenediamines from carboxylic acids under mild conditions

Monoacylated piperazine derivatives were prepared directly from carboxylic acids and piperazine using triphenylphosphine (TPP) and N-bromosuccinimide (NBS) in dichloromethane. Inexpensive and readily available reagents, excellent yields, short reaction times and mild reaction conditions are important features of this method.

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity

Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compounds of the new series maintain high nootropic activity. Moreover molecular simplification produces more clear-cut structure-activity relationships with respect to the parent series. The mechanism of action also appears to be similar in the two series. In fact, although the molecular mechanism remains to be elucidated, the most potent compound of each class (DM232 and 13, DM235) is able to increase acetylcholine release in rat brain. Piperazine derivatives represent a new class of nootropic drugs with an in vivo pharmacological profile very similar to that of piracetam, showing much higher potency with respect to the reference compound. Among the compounds studied, 13 (DM235) shows outstanding potency, being active at a dose of 0.001 mg kg-1 sc.