18903-69-0Relevant articles and documents
Synthesis and SAR of α-acylaminoketone ligands for control of gene expression
Tice, Colin M.,Hormann, Robert E.,Thompson, Christine S.,Friz, Jennifer L.,Cavanaugh, Caitlin K.,Michelotti, Enrique L.,Garcia, Javier,Nicolas, Ernesto,Albericio, Fernando
, p. 475 - 478 (2007/10/03)
A lead discovery library and a follow-up focused library of α-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS-E. The compounds were assayed in mammalian cells expressing the ecdysone receptor from Bombyx mori for their ability to cause expression of a reporter gene downstream of an ecdysone response element. The most potent α-acylaminoketones were comparable to GS-E in this assay.