18903-96-3Relevant academic research and scientific papers
Highly selective C3-H iodination of pyrrolo[1,2-a]quinoxalines
Liu, Yali,Wei, Yu,Yang, Zhen,Li, Yang,Liu, Yan,Liu, Ping
, p. 5191 - 5196 (2021)
We report a C3-H direct iodination of pyrrolo[1,2-a]quinoxalines with TBAI or I2; a series of novel 3-iodopyrrolo[1,2-a]quinoxaline derivatives were obtained with excellent regioselectivity and broad substrate scope. Mechanism studies show that a catalytic amount ofp-toluenesulfonic acid significantly promotes the selectivity and conversion of the reaction. Notably, the reaction can be performed on a gram scale, and the iodinated products can be further transformed into potentially biologically active pyrrolo[1,2-a]quinoxaline derivatives by palladium-catalyzed coupling reactions.
