189033-35-0Relevant academic research and scientific papers
Synthesis of a series of novel binucleating ligands based on 1,4,7-triazacyclononane and o-, m- and p-xylene: Crystal structure of the μ-hydroxy-bridged dicopper(II) complex [Cu2Lm(OH)2][BPh4]2 [Lm = α,α′-bis(N-1,4,7-triazacyclononane)-m-xylene]
Farrugia, Louis J.,Lovatt, Paul A.,Peacock, Robert D.
, p. 911 - 912 (1997)
The crystal structure and magnetic properties of [Cu2Lm(OH)2][BPh4]2 has been determined; Lm is one of three new binucleating ligands based on 1,4,7-triazacyclononane and o-, m- or p-xylene.
Dinuclear Fe(III) Hydroxypropyl-Appended Macrocyclic Complexes as MRI Probes
Asik, Didar,Abozeid, Samira M.,Turowski, Steven G.,Spernyak, Joseph A.,Morrow, Janet R.
, p. 8651 - 8664 (2021)
Four high-spin Fe(III) macrocyclic complexes, including three dinuclear and one mononuclear complex, were prepared toward the development of more effective iron-based magnetic resonance imaging (MRI) contrast agents. All four complexes contain a 1,4,7-triazacyclononane macrocyclic backbone with two hydroxypropyl pendant groups, an ancillary aryl or biphenyl group, and a coordination site for a water ligand. The pH potentiometric titrations support one or two deprotonations of the complexes, most likely deprotonation of hydroxypropyl groups at near-neutral pH. Variable-temperature 17O NMR studies suggest that the inner-sphere water ligand is slow to exchange with bulk water on the NMR time scale. Water proton T1 relaxation times measured for solutions of the Fe(III) complexes at pH 7.2 showed that the dinuclear complexes have a 2- to 3-fold increase in r1 relaxivity in comparison to the mononuclear complex per molecule at field strengths ranging from 1.4 T to 9.4 T. The most effective agent, a dinuclear complex with macrocycles linked through para-substitution of an aryl group (Fe2(PARA)), has an r1 of 6.7 mM-1 s-1 at 37 °C and 4.7 T or 3.3 mM-1 s-1 per iron center in the presence of serum albumin and shows enhanced blood pool and kidney contrast in mice MRI studies.
COMPOUNDS FOR USE AS IRON (III) MRI CONTRAST AGENTS CONTAINING ANIONIC PENDENTS AND ANCILLARY GROUPS
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Paragraph 0141, (2020/06/05)
Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S- substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods.
COMPOUNDS FOR USE AS IRON(III) MRI CONTRAST AGENTS
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, (2018/12/12)
Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron coordinated compoun
Using iSUSTAIN to validate the chemical attributes of different approaches to the synthesis of tacn and bridged (bis)tacn ligands
Coghlan,Campi,Jackson,Hearn
, p. 5477 - 5484 (2016/10/21)
Using green chemistry principles, alternative approaches for the synthesis of commercially important aza-macrocyclic tacn and (bis)tacn derivatives have been investigated to determine the step average and overall efficiency of these synthetic methods. Based on analytical metrics derived from the iSUSTAIN toolkit, the Richman-Atkins route for the synthesis of tacn (1) was found to be the more efficient; however an alternate route was shown to be preferable for the synthesis of (bis)tacn (2) compounds. The outcome of this study documents the importance of rigorous analysis of synthetic procedures for such aza-macrocyclic compounds in terms of their green chemistry attributes, in order to delineate how alternative synthetic methods can be ranked, more innovative procedures selected to improve productivity and yield, and synthetic methods deployed to achieve greater levels of waste reduction, reduced use of hazardous chemicals and lower environmental impact.
Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA
McCue, Kevin P.,Voss Jr., David A.,Marks, Christian,Morrow, Janet R.
, p. 2961 - 2963 (2007/10/03)
The hydrolysis of the monoribonucleotide GpppG, a model compound for the 5′-cap structure of mRNA, by dinuclear Cu(II) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second-order dependence on the catalyst was observed for two different dinuclear complexes.
