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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-(3-(trifluoromethyl)phenyl)morpholine is utilized as a key building block in the synthesis of various pharmaceuticals and agrochemicals for its medicinal properties and biological activity. Its unique structure allows for the development of compounds with specific therapeutic effects and pesticidal properties.
Used as a Ligand in Catalytic Reactions:
In the field of catalysis, 4-(3-(trifluoromethyl)phenyl)morpholine is employed as a ligand to enhance the efficiency and selectivity of certain chemical reactions. Its presence can modulate the reactivity and stability of catalysts, leading to improved outcomes in various synthetic processes.
Used as a Reagent in Organic Synthesis:
4-(3-(trifluoromethyl)phenyl)morpholine also serves as a valuable reagent in organic synthesis, where it can participate in a range of reactions, such as nucleophilic substitutions, addition reactions, and rearrangements. Its versatility and reactivity make it a useful component in the preparation of complex organic molecules and intermediates.

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Relevant academic research and scientific papers

Cobalt-Catalyzed Electrophilic Amination of Aryl- and Heteroarylzinc Pivalates with N-Hydroxylamine Benzoates

Aryl- and heteroarylzinc pivalates can be aminated with O-benzoylhydroxylamines at 25 °C within 2–4 h in the presence of 2.5–5.0 % CoCl2?2 LiCl to furnish the corresponding tertiary arylated or heteroarylated amines in good yields. This electrophilic amination also provides access to diarylamines and aryl(heteroaryl)amines. A new tuberculosis drug candidate (Q203) was prepared in six steps and 56 % overall yield by using this cobalt-catalyzed amination as the key step.

METHODS FOR FORMING ARYL CARBON-NITROGEN BONDS USING LIGHT AND PHOTOREACTORS USEFUL FOR CONDUCTING SUCH REACTIONS

The disclosure relates to a method for forming aryl carbon-nitrogen bonds and to photoreactors useful in these and other light-driven reactions. The method comprises contacting an aryl halide with an amine in the presence of a Ni salt catalyst solution and an optional base, thereby forming a reaction mixture; exposing the reaction mixture to light under reaction condition sufficient to produce the aryl carbon-nitrogen bonds. In certain embodiments, the amine may be present in a molar excess to the aryl halide. In certain embodiments, the Ni salt catalyst solution includes a Ni(II) salt and a polar solvent, wherein the Ni(II) salt is dissolved in the polar solvent. In certain embodiments, the reactions conditions include holding the reaction mixture at between about room temperature and about 80° C. for between about 1 hour and about 20 hours such that at least about 50% yield is obtained.

ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES

The present invention relates to compounds of the formula (I) wherein R1, R2, R3, X, Y and the dashed line are defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents.