189072-85-3Relevant academic research and scientific papers
Novel C-2 substituted carbapenem derivatives. Part III. Synthesis and biological activity of 2-(functionalised ethenyl, oxyiminomethyl and α-[hydroxyl benzyl)-carbapenems
Clear, Nicola J. C.,Davies, John S.,Eglington, A. John,Fell, Stephen C. M.,Hinks, Jeremy D.,Hird, Nicholas W.,Hunt, Eric,Moss, Stephen F.,Pearson, Michael J.
, p. 237 - 245 (1997)
The synthesis, antibacterial activity and stability to human dehydropeptidase-1 (DHP-1) of three small series of carbapenems carrying carbon-linked substituents at C-2 are described. C-2 Ethenyl carbapenems showed moderate antibacterial activity but poor stability to DHP-1. C-2 Oxyiminomethyl carbapenems demonstrated variable activity and stability. C-2 α-(Hydroxy)benzyl carbapenems were the most promising and showed good potency and DHP-1 stability.
