1891-10-7

Usage

Uses

2,4-Dimethoxy-omega-nitrostyrene is used as a chemical precursor for [application reason] in [application type] due to its nitro group, which allows for further chemical reactions and synthesis of other compounds. However, its specific applications are not well-documented, and more research is needed to fully understand its potential uses in various industries.

InChI:InChI=1/C10H11NO4/c1-14-9-4-3-8(5-6-11(12)13)10(7-9)15-2/h3-7H,1-2H3/b6-5+

Upstream product

• 75-52-5 nitromethane 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 860603-43-6 2,4-dimethoxy-1-(1-methoxy-2-nitro-ethyl)-benzene 
• 10125-66-3 2,4-Dimethoxy-1-<1,3-dinitro-3-methyl-butyl-2>-benzol 
• 10125-67-4 2,4-Dimethoxy-1-(1,3,3-trinitro-butyl-2)-benzol 
• 10125-68-5 2,4-Dimethoxy-1-<1,3,3-trinitro-pentyl-2>-benzol 
• 15806-29-8 2,4-dimethoxyphenethylamine 
• 138964-47-3 2-formyl-3-(2,4-dimethoxyphenyl)-4-nitropyrrole 
• 138964-40-6 2-formyl-3-(3-formyl-4,6-dimethoxyphenyl)-4-nitropyrrole 
• 1133892-30-4 1-(1,1,1-tribromo-3-nitropropan-2-yl)-2,4-dimethoxybenzene 
• 1353143-33-5 4-methoxyphenyl (3R)-3-(2,4-dimethoxyphenyl)-4-nitrobutanethioate 

Relevant academic research and scientific papers

Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents

A library of Sox-pyrrolizidines was rapidly prepared by microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition of azomethine ylides from l-proline and isatin, with various β-nitrostyrenes. Nitro-Sox compounds, 4b, 4d and 4e inhibit HEWL amyloid fibril formation by ThT studies with percentages of fluorescence intensity of 55.4, 42.9 and 40.3%, respectively. Further studies with MTT assay, Raman spectroscopy, TEM and molecular docking supported these promising candidates for activity against amyloid misfolding, a phenomenon leading to Alzheimer's disease pathology.

Synthesis and Functional Characterization of 2-(2,5-Dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine (25H-NBF) Positional Isomers

Serotonergic psychedelics, substances exerting their pharmacological action through activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a substantial fraction of the over 1000 reported New Psychoactive Substances (NPS) so far. Within this category, N-benzyl derived phenethylamines, such as NBOMes and NBFs, have shown to be of particular relevance. As these substances remain incompletely characterized, this study aimed at synthesizing positional isomers of 25H-NBF, with two methoxy groups placed on different positions of the phenyl group of the phenethylamine moiety. These isomers were then functionally characterized in an in vitro bioassay monitoring the recruitment of β-Arrestin 2 to the 5-HT2AR through luminescent readout via the NanoBiT technology. The obtained results provide insight into the optimal substitution pattern of the phenyl group of the phenethylamine moiety of N-benzyl derived substances, a feature so far mostly explored in the phenethylamines underived at the N-position. In the employed bioassay, the most potent substances were 24H-NBF (EC50 value of 158 nM), 26H-NBF (397 nM), and 25H-NBF (448 nM), with 23H-NBF, 35H-NBF, and 34H-NBF yielding μM EC50 values. A similar ranking was obtained for the compounds' efficacy: Taking as a reference LSD (lysergic acid diethylamide), 24H-, 26H-, and 25H-NBF had an efficacy of 106-107%, followed by 23H-NBF (96.1%), 34H-NBF (75.2%), and 35H-NBF (58.9%). The stronger activity of 24H-, 25H-, and 26H-NBF emphasizes the important role of the methoxy group at position 2 of the phenethylamine moiety for the in vitro functionality of NBF substances.

ZrCl4-mediated synthesis of 1,2,3-triazoles from vinyl nitrates and their biological evaluation

A ZrCl4-mediated simple method for the conversion of vinyl nitrates to 1,2,3-triazoles in excellent yields is developed. The obtained new triazoles were evaluated for their antimicrobial activity.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.