189130-14-1

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 167422-13-1 (S)-3-[(S)-2,2-Bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-3-hydroxy-6-oxo-cyclohex-1-ene-1,2-dicarboxylic acid dimethyl ester 
• 189130-18-5 2,2-Dimethyl-propionic acid (1R,2R,3S,4S,6R)-1-[(S)-2,2-bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-3-(2,2-dimethyl-propionyloxymethyl)-6-(1-ethoxy-ethoxy)-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester 
• 189130-19-6 2,2-Dimethyl-propionic acid (1R,2R,3R,6S)-2-[(S)-2,2-bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-6-(2,2-dimethyl-propionyloxymethyl)-3-(1-ethoxy-ethoxy)-2-hydroxy-5-oxo-cyclohexylmethyl ester 
• 189130-20-9 2,2-Dimethyl-propionic acid (1R,2R,3R,5S,6S)-2-[(S)-2,2-bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-6-(2,2-dimethyl-propionyloxymethyl)-3-(1-ethoxy-ethoxy)-2,5-dihydroxy-cyclohexylmethyl ester 
• 189130-16-3 (1R,2R,3S,6S,7S,9R)-7-[(S)-2,2-Bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-1-(tert-butyl-dimethyl-silanyloxy)-2-iodo-5-oxo-4,8-dioxa-tricyclo[4.2.1.0^3,7]nonane-9-carboxylic acid methyl ester 
• 189130-17-4 (1R,2R,4S,5S,6R)-1-[(S)-2,2-Bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-5,6-bis-hydroxymethyl-7-oxa-bicyclo[2.2.1]heptan-2-ol 
• 189130-15-2 (1S,4S)-1-[(S)-2,2-Bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester 
• 167422-11-9 (1S,4S)-1-[(S)-2,2-Bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[2.2.1]hept-2-ene-2,3-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure desmethyl C,D-Ring derivative of paclitaxel (Taxo(TM)) via asymmetric Diels-Alder reaction of 2-siloxyfuran

Cycloadduct 3 of the asymmetric Diels-Alder reaction of 2-siloxyfuran 2 and dimethyl acetylenedicarboxylate was converted into the enantiomerically pure desmethyl C,D-ring derivative 13 of Paclitaxel.

Enhancement of Diastereofacial Selectivity by Protecting Groups: Asymmetric Diels-Alder Reactions of 2-Siloxyfurans Derived from L-Ascorbic Acid

Diastereoselectivity in asymmetric Diels-Alder reaction of chiral 2-siloxyfurans with dimethyl acetylenedicarboxylate (DMAD) depending on the protecting groups in the allylic stereogenic centers of the molecules in the presence of the (+)-Eu(hfc)3 catalys