189134-36-9Relevant academic research and scientific papers
Application of the Grubbs ring-closing metathesis for the construction of a macrocyclic ansa-bridge. Synthesis of the tricyclic core of roseophilin
Kim, Seong Heon,Figueroa, Israel,Fuchs
, p. 2601 - 2604 (1997)
Metalation/alkylation of the pyrrole-fused 10π anion 15 regiospecifically yields the β-alkylated ketones 16,17. Conversion of 17 to diene 24 followed by Grubbs ring-closing metathesis provides 29 which is transformed to the roseophilin tricyclic core structure 5.
