189136-42-3Relevant academic research and scientific papers
Synthesis of 19-fluororetinal and 20-fluororetinal
Groesbeek, Michel,Smith, Steven O.
, p. 3638 - 3641 (2007/10/03)
We have investigated methods to monofluorinate the methyl positions 19 and 20 in retinal, and we describe a general, mild strategy that proceeds in high yields and is compatible with current carbon-13 labeling strategies. The new sequence consists of the conversion of N-methoxy-N-methylamides via the α-chloromethyl ketone to the corresponding γ-hydroxy nitrile, which can subsequently be fluorinated by (diethylamido)sulfur trifluoride (DAST).
