189149-13-1

Upstream product

• 513-74-6 ammonium dithiocarbamate 
• 5000-66-8 2-chlorophenacyl bromide 
• 2142-68-9 1-(2-chlorophenyl)ethanone 

Downstream Products

• 97556-31-5 4-(2-chloro-phenyl)-2-p-tolyldisulfanyl-thiazole 
• 97284-37-2 4-(2-chloro-phenyl)-2-(2-chloro-phenyldisulfanyl)-thiazole 
• 97359-07-4 4-(2-chloro-phenyl)-2-(2-nitro-phenyldisulfanyl)-thiazole 
• 97833-29-9 4-(2-chloro-phenyl)-2-phenyldisulfanyl-thiazole 
• 97284-38-3 4-(2-chloro-phenyl)-2-(4-chloro-phenyldisulfanyl)-thiazole 
• 189150-11-6 (4R,5S,6S)-3-[4-(2-Chloro-phenyl)-thiazol-2-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 97319-75-0 4-(2-chloro-phenyl)-2-(2,4-dinitro-phenyldisulfanyl)-thiazole 
• 97319-77-2 2-(4-chloro-2-nitro-phenyldisulfanyl)-4-(2-chloro-phenyl)-thiazole 

Relevant academic research and scientific papers

Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes

To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes (Bursaphelenchus xylophilus) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e) exhibited more than 90% mortality against Bursaphelenchus xylophilus.

Synthesis and biological properties of a new series of anti-MRSA β-Lactams; 2-(thiazol-2-ylthio)carbapenems

A series of 1β-methylcarbapenems containing variously C-2 substituted thiazol-2-ylthio groups were synthesized, and their in vitro anti-MRSA activity was examined. Among them, 1β-methyl-2-(4-arylthiazol-2-ylthio) carbapenems exhibited superior anti-MRSA activity. Introduction of a cationic moiety in the C-2 side chain not only reduced the binding to HSA but also increased the stability against DHP-I, without affecting the anti-MRSA activity. It was also found that the distance between the cationic moiety and the carbapenem skeleton was related to the strength of HSA binding and the stability against DHP-I.