18916-17-1

Usage

Uses

Used in Food Industry:
Naringin dihydrochalcone is used as an intense sweetener for its ability to provide sweetness to food products without adding significant calories. This makes it a suitable alternative for those looking to reduce their sugar intake or for individuals with diabetes.
Used in Pharmaceutical Industry:
Naringin dihydrochalcone is used as a strong antioxidant compound for its potential to protect cells from oxidative stress and damage. Its antioxidant properties make it a valuable ingredient in the development of pharmaceutical products aimed at promoting overall health and well-being.
Used in Allergy Treatment:
Naringin dihydrochalcone is used as an anti-allergic agent due to its ability to display anti-allergic activity. This application can be beneficial in the development of treatments for various allergic conditions and reactions.

InChI:InChI=1/C27H34O14/c1-11-20(33)22(35)24(37)26(38-11)41-25-23(36)21(34)18(10-28)40-27(25)39-14-8-16(31)19(17(32)9-14)15(30)7-4-12-2-5-13(29)6-3-12/h2-3,5-6,8-9,11,18,20-29,31-37H,4,7,10H2,1H3/t11-,18-,20-,21-,22+,23+,24+,25-,26-,27-/m0/s1

Upstream product

• 50376-43-7 4'-rhamnoglucosyloxy-2',4,6'-trihydroxychalcone 
• 10236-47-2 naringin 
• 10236-47-2 naringin 

Downstream Products

• 60-82-2 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on 
• 4192-90-9 4'-(β-D-glucopyranosyloxy)-2',4”,6'-trihydroxydihydrochalcone 
• 111316-17-7 4,2′,4′-trihydroxy-6′-methoxydihydrochalcone 

Relevant academic research and scientific papers

Synthetic method for naringin dihydrochalcone

The invention discloses a synthetic method for naringin dihydrochalcone. The method comprises the following steps that natural extract naringin is adopted as a raw material, alkali dissolution is performed and then filtering is performed; a polarity organic solvent is added, a catalyst is added, hydrogenation reduction is performed on the condition of the certain pressure, the catalyst is filtered away after hydrogen absorption is completed, the pH value is adjusted for crystallization, a product is obtained through filtration, and the naringin dihydrochalcone can be obtained; the liquid phase purity is 98.5% or above, and the molar yield is 96% or above.

Dihydrochalcones: Evaluation as novel radical scavenging antioxidants

Dihydrochalcones are a family of bicyclic flavonoids, defined by the presence of two benzene rings joined by a saturated three carbon bridge. In the present study, we systematically examined the antioxidant activities of dihydrochalcones against the stable free radical (1,1-diphenyl-2-picrylhydrazyl) and lipid peroxidation in the erythrocyte membrane. All dihydrochalcones exhibited higher antioxidant activities than the corresponding flavanones. The 1H NMR analysis indicated that the active dihydrochalcone has a time-averaged conformation in which the aromatic A ring is orthogonal to the carbonyl group, while the inactive dihydrochalcone such as 2′-O-methyl-phloretin has a strongly hydrogen-bonded phenolic hydroxyl group, suggestive of a coplanar conformation. A hydroxyl group at the 2′-position of the dihydrochalcone A ring, newly formed by reduction of the flavanone C ring, is an essential pharmacophore for its radical scavenging potential.