189164-76-9

Upstream product

• 129025-85-0 ethyl (R)-2-hydroxy-3-methylbutyrate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 189164-69-0 (E)-(R)-4-(4-Methoxy-benzyloxy)-5-methyl-hex-2-enoic acid methyl ester 
• 189164-70-3 (2R,3R,4R)-2,3-dihydroxy-4-(4-methoxybenzyl)oxy-5-methyl-1-hexanol 
• 189164-64-5 (R)-2-Methyl-6-(tetrahydro-pyran-2-yloxy)-hex-4-yn-3-ol 
• 189164-65-6 2-[(R)-4-(4-Methoxy-benzyloxy)-5-methyl-hex-2-ynyloxy]-tetrahydro-pyran 
• 189164-68-9 (R)-2-(4-Methoxy-benzyloxy)-3-methyl-butyric acid ethyl ester 
• 189164-66-7 (4R)-4-(4-methoxybenzyl)oxy-5-methyl-2-hexyne-1-ol 
• 189164-71-4 (2R,3R,4R)-1,2-epoxy-3-hydroxy-4-(4-methoxybenzyl)oxy-5-methylhexane 
• 189164-67-8 (4R,2E)-4-(p-methoxybenzyloxy)-5-methylhex-2-en-1-ol 
• 958018-56-9 (R)-2-(4-Methoxy-benzyloxy)-3-methyl-butyraldehyde 
• 189164-63-4 6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-methylhex-4-yn-3-one 
• 184104-18-5 (2R)-2-(4-methoxybenzyl)oxy-3-methyl-1-butanol 
• 170708-54-0 (2R,3S,6R,7S,8R)-6-hydroxy-1,2-isopropylidenedioxy-7-methoxy-8-(4-methoxybenzyl)oxy-3,9-dimethyl-4-(1,3-dithian-2-yl)-decane 

Downstream Products

• 170708-55-1 (2R,3S,6R,7S,8R)-6-(t-butyldimethylsiloxy)-1,2-dihydroxy-7-methoxy-8-(4-methoxybenzyl)oxy-3,9-dimethyl-4-(1,3-dithian-2-yl)-decane 
• 170708-51-7 (2R,3S,6R,7S,8R)-6-(t-butyldimethylsiloxy)-1,2-epoxy-7-methoxy-8-(4-methoxybenzyl)oxy-3,9-dimethyl-4-(1,3-dithian-2-yl)-decane 

Relevant academic research and scientific papers

Synthetic studies on tautomycin synthesis of segment B

The synthesis of Segment B corresponding to the C26-C17 portion of tautomycin was accomplished by coupling reaction between the epoxide (Sub-segment B-l) and the dithiane (Subsegment B-2). The degradation product of tautomycin corresponding to the C26-C19 portion was also synthesized from Sub-segment B-1.