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189194-47-6

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189194-47-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 189194-47-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,1,9 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 189194-47:
(8*1)+(7*8)+(6*9)+(5*1)+(4*9)+(3*4)+(2*4)+(1*7)=186
186 % 10 = 6
So 189194-47-6 is a valid CAS Registry Number.

189194-47-6Downstream Products

189194-47-6Relevant articles and documents

Synthesis of conformationally restricted substrate analogs and their interaction with 3-isopropylmalate dehydrogenase derived from thermus thermophilus

Chiba, Akira,Eguchi, Tadashi,Oshima, Tairo,Kakinuma, Katsumi

, p. 3537 - 3544 (1997)

The finding that 2-O-methyl-3-isopropylmalate was an uncompetitive inhibitor of 3-isopropylmalate dehydrogenase (IPMDH, EC 1.1.1.85), involved in the rate-determining step in the biosynthetic pathway of the essential amino acid L-leucine, prompted to design conformationally restricted substrate analogs, in which the hydroxy oxygen is intramolecularly bound to an isopropyl carbon to form a ring structure. The oxirane 2 was the most inhibitory among those synthesized. IPMDH appeared to recognize preferentially the anti-conformation of the butanedioic acid structure.

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