189230-90-8

Usage

Use

Intermediate in the synthesis of pharmaceuticals and organic compounds

Physical form

White solid

Melting point

68-71°C

Boiling point

339-341°C

Usage

Production of fragrances, dyes, and other organic substances

Safety precautions

Can cause irritation to the skin, eyes, and respiratory system if not handled properly.

Upstream product

• 20651-88-1 3,3-dimethyl-1,2-indanedione 
• 18949-22-9 1,1-dimethyl-2,3-diphenyl-1H-indene 
• 189230-92-0 8,8-dimethyl-1,9-diphenyl-10,11-dithiatricyclo[7.1.1.0^2,7]undeca-2,4,6-triene 
• 189230-96-4 3-[1-(2-benzoylphenyl)-1-methylethyl]-3-phenyldithiirane 
• 858510-10-8 2,3-Dihydroxy-1,1-dimethyl-2,3-diphenyl-indan 

Downstream Products

• 189230-92-0 8,8-dimethyl-1,9-diphenyl-10,11-dithiatricyclo[7.1.1.0^2,7]undeca-2,4,6-triene 
• 189230-96-4 3-[1-(2-benzoylphenyl)-1-methylethyl]-3-phenyldithiirane 

Relevant academic research and scientific papers

OXONE-ACETONE MEDIATED METAL FREE PREPARATION OF SYN-DIOLS

The present invention disclose a simple and high yielding process of Oxone-acetone mediated metal free syn-dihydroxylation of benzo fused olefins of formula (II) to obtain library of dioxolo compounds of formula (I). The invention further disclsoe a simple and high yielding process of Oxone-acetone mediated metal free syn-dihydroxylation of stilbene and its derivatives of formula (III) thereof. Also disclosed herein is Wacker-type oxidation of benzo-fused olefins of formula (X). The invention further disclose compounds of formula (I) which can be useful for the treatment of HIV, cancer or malaria.

First Synthesis and Reactivities of Isolable Dithiiranes and Their 1-Oxides

The reaction of the 6-exo-oxide of 2,2,4,4-tetramethyl-1,5-diphenyl-6,7-dithiabicyclo[3.1.1]heptane (2) with 2KHSO5·KHSO4·K2SO4 gave the first isolable dithiirane oxide, (1RS, 3SR)-3-phenyl-3-(1,1,3,3-tetramethyl-4-oxo-4-phenylbutyl)dithiirane 1-oxide (1), while the 6-endo-oxide of 2 gave both 1 and its (1RS, 3RS)-isomer 10. Under similar reaction conditions, 2 yielded the first isolable, unoxidized dithiirane, 3-phenyl-3-(1,1,3,3-tetramethyl-4-oxo-4-phenylbutyl)dithiirane (3). The dithiirane 3 was also obtained by treatment of 2 with NaOCl-NaClO4. The X-ray structure analyses were performed for 1, 3, and 10. Treatment of unsymmetrical 8,8-dimethyl-1,9-diphenyl-10,11-dithiatricyclo[7.1.1.0 2,7]-undeca-2,4,6-triene with NaOCl-NaClO4 gave 3-[1-(o-benzoylphenyl)-1-methylethyl]-3-phenyldithiirane selectively in good yield. However, 1,3-dithietanes, prepared from adamantane-2-thiones, failed to give the corresponding dithiiranes by treatment with 2KHSO5·KHSO4·K2SO4 or NaOCl-NaClO4. The dithiirane 3 thermally isomerized to 2,2,4,4-tetramethyl-1,5-diphenyl-8-oxa-6,7-dithiabicyclo[3.2.1 ]octane probably via 2,2,4,4-tetramethyl-1,5-diphenyl-5-thioxo-1-pentanone S-sulfide.