189231-43-4

Usage

Chiral compound

(R)-enantiomer is the biologically active form

Building block

used in the synthesis of various pharmaceuticals and organic compounds

Therapeutic potential

for the treatment of neurodegenerative diseases and cancer

Antimicrobial properties

has been studied for its antifungal properties

Versatile and valuable

has a range of potential applications in medicine and chemistry.

Upstream product

• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 136571-61-4 1-methyl-4-chloro-2-butenal 

Downstream Products

• 222629-69-8 (3R)-3-isopropyl-7a-methyl-2,3-dihydropyrrolo[2,1-b][1,3]oxazol-5(7aH)-one 

Relevant academic research and scientific papers

Conversion of homochiral amines, β-amino alcohols and α-amino acids to their chiral 2-methylpyrrole derivatives

5-Chloro-3-penten-2-one reacts with the amino group of homochiral amines, amino alcohols, amino acid esters to form corresponding 2-pyrrole derivatives in good yield and without racemization.

Synthesis and photooxygenation of homochiral 2-methylpyrrole derivatives of chiral amino alcohols: Simple, selective access to chiral bicyclic lactams

Homochiral 2-methylpyrrole derivatives are synthesized in high yields starting from chiral amino alcohols and 5-chloro-3-pentene-2-one. The photooxygenation of these compounds in the presence of a photosynthesizer furnishes the pyrrolooxazolone structures in high diastereoselectivities. In all of the examples, trans-isomers are formed as the major products.